Natural regulatory T cells control the development of atherosclerosis in mice

被引：898

作者：

Ait-Oufella, H

Salomon, BL

Potteaux, S

Robertson, AKL

Gourdy, P

Zoll, J

Merval, R

Esposito, B

Cohen, JL

Fisson, S

Flavell, RA

Hansson, GK

Klatzmann, D

Tedgui, A

Mallat, Z

机构：

[1] Ctr Rech Cardiovasc Lariboisiere, INSERM, U689, F-75010 Paris, France

[2] Grp Hosp Pitie Salpetriere, CNRS, UMR 7087, F-75013 Paris, France

[3] Karolinska Inst, Karolinska Hosp, Dept Med, Ctr Mol Med, SE-17176 Stockholm, Sweden

[4] Inst L Bugnard, INSERM, U589, F-31432 Toulouse 4, France

[5] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

[6] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

NATURE MEDICINE | 2006年 / 12卷 / 02期

关键词：

D O I：

10.1038/nm1343

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke(1,2). Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens(3,4), are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.

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收藏

页码：178 / 180

页数：3

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