A quantitative trait locus for live weight maps to bovine Chromosome 23

被引：34

作者：

Elo, KT ^{[1
]}

Vilkki, J ^{[1
]}

de Koning, DJ ^{[1
]}

Velmala, RJ ^{[1
]}

Mäki-Tanila, AV ^{[1
]}

机构：

[1] Agr Res Ctr MTT, Anim Prod Res, Anim Breeding, FIN-31600 Jokioinen, Finland

来源：

MAMMALIAN GENOME | 1999年 / 10卷 / 08期

关键词：

D O I：

10.1007/s003359901098

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A multiple-marker mapping approach was used to search for quantitative trait loci (QTLs) affecting production, health, and fertility traits in Finnish Ayrshire dairy cattle. As part of a whole-genome scan, altogether 469 bulls were genotyped for six microsatellite loci in 12 families on Chromosome (Chr) 23. Both multiple-marker interval mapping with regression and maximum-likelihood methods were applied with a granddaughter design. Eighteen traits, belonging to 11 trait groups, were included in the analysis. One QTL exceeded experiment level and one QTL genome level significance thresholds. Across-families analysis provided strong evidence (P-experiment = 0.0314) for a QTL affecting live weight. The QTL for live weight maps between markers BM1258 and BoLA DRBP1. A QTL significant at genome level (P-genome = 0.0087) was mapped for veterinary treatment, and the putative QTL probably affects susceptibility to milk fever or ketosis. In addition, three traits exceeded the chromosome 5% significance threshold: protein percentage of milk, calf mortality (sire), and milking speed. In within-family analyses, protein percentage was associated with markers in one family (LOD score = 4.5).

引用

页码：831 / 835

页数：5

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