Regioselective synthesis of alpha-L-fucosyl-containing benzyl disaccharides by use of alpha-L-fucosidases of Aspergillus niger

The activity of fucosidase shows different Value depending on disease, eg) fucosidosis and 1 cell disease are characterized by the absence or deficiences of alpha-fucosidase, and sera of ovarian cancer patients exhibited a statistically significant deficiency of alpha-L-fucosidase activity (Zielke ef al., 1972; Kress et al., 1980; Barrow et al., 1981). For the purpose of diagnosis of these disease easily, the manual of test can be developed by preparing kits of hydrophobic-binding substrate of fucosidase that bind C18-column.