Sonhafouonic acid, a new cytotoxic and antifungal hopene-triterpenoid from Zehneria scabra camerunensis

被引：11

作者：

Kongue, Michel D. T. ^{[1
]}

Talontsi, Ferdinand M. ^{[2
]}

Lamshoeft, Marc ^{[2
]}

Kenla, Timothee J. N. ^{[1
]}

Dittrich, Birger ^{[3
]}

Kapche, Gilbert D. W. F. ^{[1
]}

Spiteller, Michael ^{[2
]}

机构：

[1] Univ Yaounde I, ENS, Dept Chem, Yaounde, Cameroon

[2] TU Dortmund, Fac Chem, Inst Environm Res INFU, Otto Hahn Str 6, D-44221 Dortmund, Germany

[3] Univ Gottingen, Inst Inorgan Chem, D-37077 Gottingen, Germany

来源：

FITOTERAPIA | 2013年 / 85卷

关键词：

Zheneria scabra camerunensis; Cucurbitaceae; Natural products; Antifungal; Cytotoxicity; HOPANE; NMR;

D O I：

10.1016/j.fitote.2013.01.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new hopene-type triterpenoid, namely sonhafouonic acid la was isolated from Zehneria scabra camerunensis, together with eight known compounds. The structure of la was established by extensive NMR and high resolution MS techniques and confirmed by single-crystal X-ray crystallographic analysis. Compound la exhibited inhibitory activity against mycelia] growth of two peronosporomycete phytopathogens Pythium ultimum and Aphanomyces cochliodes and cytotoxicity towards brine shrimp larvae (Artemia sauna) at 10 mu g/mL. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：176 / 180

页数：5

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