One-step synthesis of radioiodinated biotin derivatives

被引：8

作者：

Foulon, CF ^{[1
]}

Adelstein, SJ ^{[1
]}

Kassis, AI ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 07期

关键词：

D O I：

10.1016/0960-894X(96)00106-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A direct method of radioiodination of biotin derivatives is presented whereby radiolabeled sodium iodide is exchanged with a tributylstannyl group under oxidative conditions. The in vitro binding of each radioiodinated biotin derivative to streptavidin is saturable acid three of the compounds exhibit a strong affinity for streptavidin. All the biotin-streptavidin complexes are rapidly catabolized in human serum. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：779 / 784

页数：6

共 11 条

[1] PROPERTIES OF STREPTAVIDIN BIOTIN-BINDING PROTEIN PRODUCED BY STREPTOMYCETES [J].