The role of adiponectin in atherosclerosis and thrombosis

被引：63

作者：

Ekmekci, Hakan

Ekmekci, Ozlem B.

机构：

[1] Istanbul Univ, Fac Med, Dept Pediat Haematol & Oncol, Istanbul, Turkey

[2] Istanbul Univ, Bone Marrow Transplantat Unit, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2006年 / 12卷 / 02期

关键词：

adiponectin; atheroscierosis; thrombosis;

D O I：

10.1177/107602960601200203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a major risk factor for morbidity and mortality from cardiovascular causes. Adiponectin has been identified recently as one of the adipocytokines with important metabolic effects. it can suppress atherogenesis by inhibiting the adherence of monocytes, reducing their phagocytic activity, and suppressing the accumulation of modified lipoproteins in the vascular wall. In addition, as adiponectin decrease endothelial damage and stimulates production of NO from vascular endothelial cells, hypoadiponectinemia may be partially contribute to thrombus formation.

引用

收藏

页码：163 / 168

页数：6

相关论文

共 48 条

[1] Decreased plasma adiponectin concentration in patients with essential hypertension [J].

Adamczak, M ;

Wiecek, A ;

Funahashi, T ;

Chudek, J ;

Kokot, F ;

Matsuzawa, Y .

AMERICAN JOURNAL OF HYPERTENSION, 2003, 16 (01) :72-75

[2] Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Maeda, K ;

Kuriyama, H ;

Okamoto, Y ;

Kumada, M ;

Hotta, K ;

Nishida, M ;

Takahashi, M ;

Nakamura, T ;

Shimomura, I ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

CIRCULATION, 2002, 105 (24) :2893-2898

[3] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Takahashi, M ;

Maeda, K ;

Miyagawa, J ;

Hotta, K ;

Shimomura, I ;

Nakamura, T ;

Miyaoka, K ;

Kuriyama, H ;

Nishida, M ;

Yamashita, S ;

Okubo, K ;

Matsubara, K ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83

[4] ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism [J].

Berg, AH ;

Combs, TP ;

Scherer, PE .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (02) :84-89

[5] Body-mass index and mortality in a prospective cohort of US adults [J].

Calle, EE ;

Thun, MJ ;

Petrelli, JM ;

Rodriguez, C ;

Heath, CW .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (15) :1097-1105

[6] Adiponectin: More than just another fat cell hormone? [J].

Chandran, M ;

Phillips, SA ;

Ciaraldi, T ;

Henry, RR .

DIABETES CARE, 2003, 26 (08) :2442-2450

[7] Adiponectin stimulates production of nitric oxide in vascular endothelial cells [J].

Chen, H ;

Montagnani, M ;

Funahashi, T ;

Shimomura, I ;

Quon, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (45) :45021-45026

[8] Obesity in the new millennium [J].

Friedman, JM .

NATURE, 2000, 404 (6778) :632-634

[9] Endothelial function, inflammation, and prognosis in cardiovascular disease [J].

Gonzalez, MA ;

Selwyn, AP .

AMERICAN JOURNAL OF MEDICINE, 2003, 115 :99-106

[10] Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue [J].

Halleux, CM ;

Takahashi, M ;

Delporte, ML ;

Detry, R ;

Funahashi, T ;

Matsuzawa, Y ;

Brichard, SM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 288 (05) :1102-1107

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