Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report

被引：87

作者：

Cohn, Tony A. ^{[1
]}

Remington, Gary

Zipursky, Robert B.

Azad, Azar

Connolly, Philip

Wolever, Thomas M. S.

机构：

[1] Ctr Addict & Mental Hlth, Schizophrenia Program, Medicat Assessment Program Schiophrenia, 1001 Queen St W, Toronto, ON M6J 1H4, Canada

[2] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON M5S 1A1, Canada

[3] Univ Toronto, Fac Med, Core Lab, Banting & Best Diabet Ctr, Toronto, ON, Canada

[4] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada

[5] St Michaels Hosp, Lipid Res Lab, JA Little Lipid Res Lab, Toronto, ON M5B 1W8, Canada

来源：

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 2006年 / 51卷 / 06期

关键词：

schizophrenia; drug-free; insulin resistance; adiponectin; diabetes susceptibility; frequently sampled intravenous glucose tolerance test; Bergman's minimal model;

D O I：

10.1177/070674370605100608

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To compare the insulin sensitivity and adiponectin levels of medication-free patients suffering from schizophrenia or schizoaffective disorder with that of matched healthy volunteers. Method: We evaluated 9 nondiabetic patients aged 26.6 years (median 26 years, range 17 to 41 years) and matched volunteers, using the frequently sampled intravenous glucose tolerance test, minimal model analysis, and fasting adiponectin levels. Results: The mean insulin sensitivity index of the patients was 42% lower than that of the healthy volunteers (P = 0.026), with inadequate compensation in insulin secretion. Patients with schizophrenia tended to have reduced adiponectin levels (P = 0.055). Conclusions: By direct measurement, this study provides evidence of insulin resistance and susceptibility to type 2 diabetes in patients with schizophrenia who are free of antipsychotic drugs.

引用

页码：382 / 386

页数：5

共 13 条

[1]

Amer Diabet Assoc, 2005, DIABETES CARE, V28, pS37

[2]

[Anonymous], 2000, DIAGN STAT MAN MENT

[3] Insulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients [J].

Arranz, B ;

Rosel, P ;

Ramírez, N ;

Dueñas, R ;

Fernández, P ;

Sanchez, JM ;

Navarro, MA ;

San, L .

JOURNAL OF CLINICAL PSYCHIATRY, 2004, 65 (10) :1335-1342

[4] EQUIVALENCE OF THE INSULIN SENSITIVITY INDEX IN MAN DERIVED BY THE MINIMAL MODEL METHOD AND THE EUGLYCEMIC GLUCOSE CLAMP [J].

BERGMAN, RN ;

PRAGER, R ;

VOLUND, A ;

OLEFSKY, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) :790-800

[5]

*CAN DIAB ASS CLIN, 2003, CAN J DIABETES S2, V27, pS1

[6] Prevalence and correlates of diabetes in national schizophrenia samples [J].

Dixon, L ;

Weiden, P ;

Delahanty, J ;

Goldberg, R ;

Postrado, L ;

Lucksted, A ;

Lehman, A .

SCHIZOPHRENIA BULLETIN, 2000, 26 (04) :903-912

[7] REPRODUCIBILITY OF INSULIN SENSITIVITY MEASURED BY THE MINIMAL MODEL METHOD [J].

FERRARI, P ;

ALLEMAN, Y ;

SHAW, S ;

RIESEN, W ;

WEIDMANN, P .

DIABETOLOGIA, 1991, 34 (07) :527-530

[8] A MODIFIED PROTOCOL FOR ESTIMATION OF INSULIN SENSITIVITY WITH THE MINIMAL MODEL OF GLUCOSE KINETICS IN PATIENTS WITH INSULIN-DEPENDENT DIABETES [J].

FINEGOOD, DT ;

HRAMIAK, IM ;

DUPRE, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (06) :1538-1549

[9] Diabetes mellitus and schizophrenia: historical perspective [J].

Kohen, D .

BRITISH JOURNAL OF PSYCHIATRY, 2004, 184 :S64-S66

[10] Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia [J].

Ryan, MCM ;

Collins, P ;

Thakore, JH .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (02) :284-289

← 1 2 →