3-Hydroxychromones as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation

被引：41

作者：

Lee, Jinho

Park, Taesik

Jeong, Shinwu

Kim, Kyoung-Hee

Hong, Changyong

机构：

[1] Keimyung Univ, Dept Chem, Taegu 704701, South Korea

[2] LG Life Sci, Taejon 305380, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 05期

关键词：

3-hydroxychromone; isothiazolidine 1,1-dioxide; CDK2;

D O I：

10.1016/j.bmcl.2006.12.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A novel series of 3-hydroxychrornones were prepared and found to be CDK inhibitors. lsothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT 116, SW620, and MDAMB468 cancer cells. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1284 / 1287

页数：4

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