The first hydrophobic domain of the hepatitis C virus E1 protein is important for interaction with the capsid protein

被引：27

作者：

Ma, HC

Ke, CH

Hsieh, TY

Lo, SY ^{[1
]}

机构：

[1] Buddhist Tzu Chi Gen Hosp, Dept Med Technol, Hualien, Taiwan

[2] Tzu Chi Univ, Inst Med Res, Hualien 970, Taiwan

[3] Tzu Chi Univ, Dept Med Technol, Hualien 970, Taiwan

[4] Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Internal Med, Taipei, Taiwan

来源：

JOURNAL OF GENERAL VIROLOGY | 2002年 / 83卷

关键词：

D O I：

10.1099/0022-1317-83-12-3085

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The interaction between the hepatitis C virus capsid protein and the envelope protein E1 has been demonstrated previously in vivo. To determine the binding region of the E1 protein with the capsid protein, this interaction was characterized in vitro. This study shows that the interaction between these proteins should occur in the endoplasmic reticulum membrane rather than in the cytosol and that the first hydrophobic domain of the E1 protein (aa 261-291) is important for the interaction with the capsid protein.

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页码：3085 / 3091

页数：7

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