Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

被引：10

作者：

Fruscella, P ^{[1
]}

Romano, M ^{[1
]}

Albani, D ^{[1
]}

Bernasconi, S ^{[1
]}

Luini, W ^{[1
]}

Bruno, A ^{[1
]}

Salmona, M ^{[1
]}

Diomede, L ^{[1
]}

机构：

[1] Mario Negri Inst Pharmacol Res, Dept Mol Pharmacol & Biochem, I-20157 Milan, Italy

来源：

CYTOKINE | 2000年 / 12卷 / 07期

关键词：

chemokines; cholesterol; HMG-CoA reductase; MCP-1; rodent;

D O I：

10.1006/cyto.1999.0602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.

引用

页码：1100 / 1103

页数：4

共 16 条

[1] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, MS
Goldstein, JL
[J]. CELL, 1997, 89 (03) : 331 - 340
[2] Chronic infections and coronary heart disease: is there a link?
Danesh, J
Collins, R
Peto, R
[J]. LANCET, 1997, 350 (9075) : 430 - 436
[3] A 48-WELL MICRO CHEMOTAXIS ASSEMBLY FOR RAPID AND ACCURATE MEASUREMENT OF LEUKOCYTE MIGRATION
FALK, W
GOODWIN, RH
LEONARD, EJ
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1980, 33 (03) : 239 - 247
[4] FEINGOLD KR, 1995, J LIPID RES, V36, P1474
[5] FOLCH J, 1957, J BIOL CHEM, V226, P497
[6] REGULATION OF THE MEVALONATE PATHWAY
GOLDSTEIN, JL
BROWN, MS
[J]. NATURE, 1990, 343 (6257) : 425 - 430
[7] HARDARDOTTIR I, 1994, LYMPHOKINE CYTOK RES, V13, P161
[8] FEEDBACK-REGULATION OF 3-HYDROXY-3-METHYGLUTARYL COENZYME A REDUCTASE IN LIVERS OF MICE TREATED WITH MEVINOLIN, A COMPETITIVE INHIBITOR OF THE REDUCTASE
KITA, T
BROWN, MS
GOLDSTEIN, JL
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1980, 66 (05) : 1094 - 1100
[9] Chronic Chlamydia pneumoniae infection is associated with a serum lipid profile known to be a risk factor for atherosclerosis
Laurila, A
Bloigu, A
Nayha, S
Hassi, J
Leinonen, M
Saikku, P
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) : 2910 - 2913
[10] TUMOR-NECROSIS-FACTOR MEDIATES THE EFFECTS OF ENDOTOXIN ON CHOLESTEROL AND TRIGLYCERIDE-METABOLISM IN MICE
MEMON, RA
GRUNFELD, C
MOSER, AH
FEINGOLD, KR
[J]. ENDOCRINOLOGY, 1993, 132 (05) : 2246 - 2253

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