Allelic imbalance in selected chromosomal regions in ovarian cancer

被引：27

作者：

Hansen, LL

Jensen, LL

Dimitrakakis, C

Michalas, S

Gilbert, F

Barber, HRK

Overgaard, J

Arzimanoglou, II

机构：

[1] Aarhus Univ, Dept Human Genet, DK-8000 Aarhus C, Denmark

[2] Alexandras Univ Hosp, Sch Med, Dept Obstet & Gynaecol 1, Athens 11528, Greece

[3] Cornell Univ, Weill Med Coll, Div Human Genet, New York, NY 10021 USA

[4] Cornell Univ, Weill Med Coll, Dept Obstet & Gynecol, New York, NY 10021 USA

[5] Aarhus Univ Hosp, Dept Expt Clin Oncol, DK-8000 Aarhus C, Denmark

来源：

CANCER GENETICS AND CYTOGENETICS | 2002年 / 139卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(02)00620-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ovarian cancer (OC) is often asymptomatic at the initial stage. When diagnosed, up to 75% of the patients present grade III or IV tumors with metastasis in nearby organs of the abdomen. Genetic imbalance is abundant in OC, and allelic loss (AL) of specific chromosomal regions is considered an early event. To establish association between genetic markers for early diagnosis/prognosis of OC, our target was to define narrow specific regions of AL. We analyzed 65 ovarian carcinomas by using 19 microsatellite markers located in three different chromosomes. First, a 7.6-Mb region containing the estrogen receptor (ESR1) and the tumor suppressor gene LATS1 was analyzed. Several chromosomal breakpoints flanking ESR1 affecting the region harboring LATS1 were found. Second, we found chromosomal breakpoints on 13q13.1similar toq13.3 that defined two narrow regions flanking the BRCA2 locus. Third, our ovarian tumors exhibited a very high frequency of AL on 16q and chromosomal breakpoints defining two narrow regions within 16q22.2similar toq24.3. In this article, we report three new polymorphic microsatellite markers and strong evidence of AL of narrow well-defined regions in hot spots on 6q, 13q, and 16q in ovarian tumors. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1 / 8

页数：8

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