Antioxidant and cytotoxic activities of Hypericum sp on brine shrimps and human cancer cell lines

被引：39

作者：

Couladis, M ^{[1
]}

Badisa, RB

Baziou, P

Chaudhuri, SK

Pilarinou, E

Verykokidou, E

Harvala, C

机构：

[1] Univ Athens, Dept Pharm, Div Pharmacognosy, GR-15771 Athens, Greece

[2] Walker Canc Res Inst, Tallahassee, FL 32308 USA

来源：

PHYTOTHERAPY RESEARCH | 2002年 / 16卷 / 08期

关键词：

Hypericum sp; cytotoxicity; brine shrimps; Caco-2; cells; HepG2; antioxidant activity;

D O I：

10.1002/ptr.1042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten different samples of five Hypericum sp. were tested on brine shrimps, human colon carcinoma and human hepatoma cell lines for their cytotoxic activities. H. triquetrifolium Turra. (Rafina) showed the highest activity (LC50 = 22 mg/mL) on brine shrimps, while the extracts of the other nine samples showed significant to moderate activities (LC50 from 37 to 107 mg/mL). H. empetrifolium Wild. (Parnon) showed the highest activity in human colon carcinoma and human hepatoma cell lines, with LC50 values 29 and 25.1 mg/mL, respectively, while the LC50 values of the other samples were more than 45 mg/mL. It is very interesting to observe that most Hypericum samples showed good antioxidant activity in vitro. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：719 / 722

页数：4

共 18 条

[1] A Blind Comparison of Simple Bench-top Bioassays and Human Tumour Cell Cytotoxicities as Antitumor Prescreens [J].

Anderson, J. E. ;

Goetz, C. M. ;

McLaughlin, J. L. ;

Suffness, M. .

PHYTOCHEMICAL ANALYSIS, 1991, 2 (03) :107-111

[2] Licania michauxii Prance root extract induces hsp 70 mRNA and necrotic cell death in cultured human hepatoma and colon carcinoma cell lines [J].

Badisa, RB ;

Chaudhuri, SK ;

Pilarinou, E ;

Rutkoski, NJ ;

Hare, J ;

Levenson, CW .

CANCER LETTERS, 2000, 149 (1-2) :61-68

[3]

BLUMENTHAL M, 1998, COMPLETE GERMAN COMM, P214

[4] Antioxidant activity of Argyranthemum spp. aerial parts [J].

Couladis, M ;

Tsortanidou, V ;

Verykokidou, E ;

Francisco-Ortega, J ;

Santos-Guerra, A ;

Harvala, C .

PHARMACEUTICAL BIOLOGY, 2001, 39 (01) :54-56

[5] LIPID-PEROXIDATION BY BLEOMYCIN-IRON COMPLEXES INVITRO [J].

EKIMOTO, H ;

TAKAHASHI, K ;

MATSUDA, A ;

TAKITA, T ;

UMEZAWA, H .

JOURNAL OF ANTIBIOTICS, 1985, 38 (08) :1077-1082

[6] Role of monensin PLGA polymer nanoparticles and liposomes as potentiator of ricin A immunotoxins in vitro [J].

Ferdous, AJ ;

Stembridge, NY ;

Singh, M .

JOURNAL OF CONTROLLED RELEASE, 1998, 50 (1-3) :71-78

[7]

HARRER G, 1994, J GERIATRIC PSYCH S1, V7, P6

[8]

ISHIGURO K, 1990, PLANTA MED, V56, P274, DOI 10.1055/s-2006-960955

[9] St John's wort for depression - An overview and meta-analysis of randomised clinical trials [J].

Linde, K ;

Ramirez, G ;

Mulrow, CD ;

Pauls, A ;

Weidenhammer, W ;

Melchart, D .

BRITISH MEDICAL JOURNAL, 1996, 313 (7052) :253-258

[10] Comparison of relative antioxidant activities of British medicinal plant species in vitro [J].

Mantle, D ;

Eddeb, F ;

Pickering, AT .

JOURNAL OF ETHNOPHARMACOLOGY, 2000, 72 (1-2) :47-51

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