A unique role for the human amygdala in novelty detection

被引：116

作者：

Blackford, Jennifer Urbano ^{[1
]}

Buckholtz, Joshua W. ^{[2
]}

Avery, Suzanne N.

Zald, David H. ^{[2
]}

机构：

[1] Vanderbilt Univ, Psychiat Neuroimaging Program, Dept Psychiat, Sch Med, Nashville, TN 37212 USA

[2] Vanderbilt Univ, Dept Psychol, Nashville, TN 37212 USA

来源：

NEUROIMAGE | 2010年 / 50卷 / 03期

关键词：

Amygdala; Hippocampus; Novelty; Contextual novelty; Categorical novelty; fMRI; MEDIAL TEMPORAL-LOBE; EVENT-RELATED FMRI; HUMAN HIPPOCAMPUS; VISUAL-CORTEX; STIMULI; AROUSAL; SINGLE; MEMORY; RECOGNITION; EMOTION;

D O I：

10.1016/j.neuroimage.2009.12.083

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous research indicates that the amygdala and hippocampus are sensitive to novelty; however, two types of novelty can be distinguished - stimuli that are ordinary, but novel in the current context, and stimuli that are unusual. Using functional magnetic resonance imaging, we examined blood oxygen dependent level (BOLD) response of the human amygdala and hippocampus to novel, commonly seen objects versus novel unusual objects. When presented with the novel common stimuli, the BOLD signal increased significantly in both the amygdala and hippocampus. However, for the novel unusual stimuli, only the amygdala showed an increased response compared to the novel common stimuli. These findings suggest that the amygdala is distinctly responsive to novel unusual stimuli, making a unique contribution to the novelty detection circuit. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1188 / 1193

页数：6

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