Expression of interleukin-6 messenger RNA in a rat model of diffuse axonal injury

被引：15

作者：

Rhodes, JKJ

Andrews, PJD

Holmes, MC

Seckl, JR

机构：

[1] Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Dept Mol Endocrinol, Edinburgh EH4 2XU, Midlothian, Scotland

[2] Western Gen Hosp, Intens Care Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NEUROSCIENCE LETTERS | 2002年 / 335卷 / 01期

关键词：

brain injury; in situ hybridisation; interleukin-6; rodent model;

D O I：

10.1016/S0304-3940(02)00811-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Having demonstrated a transcranial gradient of the cytokine interleukin-6 (IL-6) in patients with either traumatic brain injury or spontaneous subarachnoid haemorrhage we have employed in situ hybridisation for IL-6 messenger RNA (mRNA) to determine the site of this IL-6 production within the central nervous system (CNS). A rodent weight drop model of traumatic brain injury was used. IL-6 mRNA levels in brains were determined 6 h after injury. Sham animals had normal constitutive expression for IL6 mRNA. In traumatised animals an intense area of IL-6 mRNA labelling was found below the hippocampus. Cells strongly expressing IL-6 mRNA were also seen in the dentate gyrus. This inflammatory cytokine is clearly implicated in the response to CNS injury, but whether this response is neuroprotective or pathological is uncertain. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

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