Metallic Scaffolds for Bone Regeneration

被引：412

作者：

Alvarez, Kelly ^{[2
]}

Nakajima, Hideo ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan

[2] Akita Univ, Fac Engn & Resource Sci, Ctr Geoenvironm Sci, Akita 0108502, Japan

来源：

MATERIALS | 2009年 / 2卷 / 03期

关键词：

metallic bone scaffolds; biocompatible metals; load-bearing porous structures; 3-D metallic constructs; bone tissue engineering; TITANIUM FIBER MESH; POROUS NICKEL-TITANIUM; BIODEGRADABLE MAGNESIUM SCAFFOLDS; TOTAL HIP-ARTHROPLASTY; SHAPE-MEMORY ALLOYS; IN-VIVO CORROSION; MECHANICAL-PROPERTIES; INTERBODY FUSION; TRABECULAR BONE; 3-DIMENSIONAL SCAFFOLDS;

D O I：

10.3390/ma2030790

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Bone tissue engineering is an emerging interdisciplinary field in Science, combining expertise in medicine, material science and biomechanics. Hard tissue engineering research is focused mainly in two areas, osteo and dental clinical applications. There is a lot of exciting research being performed worldwide in developing novel scaffolds for tissue engineering. Although, nowadays the majority of the research effort is in the development of scaffolds for non-load bearing applications, primarily using soft natural or synthetic polymers or natural scaffolds for soft tissue engineering; metallic scaffolds aimed for hard tissue engineering have been also the subject of in vitro and in vivo research and industrial development. In this article, descriptions of the different manufacturing technologies available to fabricate metallic scaffolds and a compilation of the reported biocompatibility of the currently developed metallic scaffolds have been performed. Finally, we highlight the positive aspects and the remaining problems that will drive future research in metallic constructs aimed for the reconstruction and repair of bone.

引用

页码：790 / 832

页数：43

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