Virulence and transmissibility of pathogens: What is the relationship?

被引：230

作者：

Lipsitch, M ^{[1
]}

Moxon, ER ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP, INST MOL MED, DEPT PAEDIAT, MOL INFECT DIS GRP, OXFORD OX3 9DU, ENGLAND

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 01期

关键词：

D O I：

10.1016/S0966-842X(97)81772-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fitness of most pathogenic microorganisms depends on transmission from host to host. This requires adaptation for dissemination, translocation and survival between hosts, as well as for colonization. A complex relationship exists between these components of microbial fitness and virulence. Understanding this relationship has important implications for research and public health.

引用

页码：31 / 37

页数：7

共 69 条

[1] ANDERSON R M, 1991
[2] COEVOLUTION OF HOSTS AND PARASITES
ANDERSON, RM
MAY, RM
[J]. PARASITOLOGY, 1982, 85 (OCT) : 411 - 426
[3] [Anonymous], 1992, EMERGING INFECT MICR
[4] WITHIN-HOST POPULATION-DYNAMICS AND THE EVOLUTION AND MAINTENANCE OF MICROPARASITE VIRULENCE
ANTIA, R
LEVIN, BR
MAY, RM
[J]. AMERICAN NATURALIST, 1994, 144 (03) : 457 - 472
[5] Models of the within-host dynamics of persistent mycobacterial infections
Antia, R
Koella, JC
Perrot, V
[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1996, 263 (1368) : 257 - 263
[6] HAEMOPHILUS-INFLUENZAE TYPE-B CARRIAGE AND IMMUNITY 4 YEARS AFTER RECEIVING THE HAEMOPHILUS-INFLUENZAE OLIGOSACCHARIDE-CRM(197) (HBOC) CONJUGATE VACCINE
BARBOUR, ML
BOOY, R
CROOK, DWM
GRIFFITHS, H
CHAPEL, HM
MOXON, ER
MAYONWHITE, D
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (06) : 478 - 484
[7] MUTATION AND THE EVOLUTION OF VIRULENCE
BONHOEFFER, S
NOWAK, MA
[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 258 (1352) : 133 - 140
[8] INTRA-HOST VERSUS INTER-HOST SELECTION - VIRAL STRATEGIES OF IMMUNE FUNCTION IMPAIRMENT
BONHOEFFER, S
NOWAK, MA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (17) : 8062 - 8066
[9] A GAME-THEORETICAL MODEL OF PARASITE VIRULENCE
BREMERMANN, HJ
PICKERING, J
[J]. JOURNAL OF THEORETICAL BIOLOGY, 1983, 100 (03) : 411 - 426
[10] Buchmeier M J, 1980, Adv Immunol, V30, P275, DOI 10.1016/S0065-2776(08)60197-2

← 1 2 3 4 5 6 7 →