Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep

被引：28

作者：

Arndt, ML ^{[1
]}

Wu, DL ^{[1
]}

Soong, Y ^{[1
]}

Szeto, HH ^{[1
]}

机构：

[1] Cornell Univ, Sch Med, Dept Pharmacol, New York, NY 10021 USA

来源：

PEPTIDES | 1999年 / 20卷 / 04期

关键词：

ORL; nociceptin; adrenergic; phenoxybenzamine; propranolol;

D O I：

10.1016/S0196-9781(99)00027-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was undertaken to examine the cardiovascular effects of nociceptin/Orphanin FQ (OFQ). Nociceptin/OFQ (10-300 nmol/kg, IV) stimulates an increase in mean blood pressure (MBP) and heart rate (HR) in chronically catheterized sheep. Pretreatment with phenoxybenzamine (5 mg/kg) attenuated the presser response, consistent with sympathetically mediated vasoconstriction. Furthermore, the lack of a reflex bradycardia suggests either blunting of the baroreflex by nociceptin/OFQ or direct beta-adrenergic activation. The bradycardic response to norepinephrine (0.6 mu g/kg, IV) remained intact after nociceptin/OFQ administration, demonstrating that nociceptin/OFQ does not blunt the baroreflex. Additionally, the increase in HR was completely reversed by pretreatment with propranolol. These data suggest that nociceptin/OFQ plays a role in cardiovascular regulation via sympathetic activation. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：465 / 470

页数：6

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