Granulysin: a lethal weapon of cytolytic T cells

被引：77

作者：

Stenger, S ^{[1
]}

Rosat, JP

Bloom, BR

Krensky, AM

Modlin, RL

机构：

[1] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, D-91054 Erlangen, Germany

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90095 USA

[3] Stanford Univ, Dept Pediat, Div Immunol & Transplantat Biol, Stanford, CA 94305 USA

[4] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 09期

关键词：

D O I：

10.1016/S0167-5699(99)01449-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) T cells protect against infection form intracellular bacteria and parasites by lysing infected targets. Here, a novel mechanism is discussed in which CD8(+) cytolytic T cells directly destroy intracellular pathogens by releasing nn antimicrobial protein, granulysin, from cytotoxic granules.

引用

页码：390 / 394

页数：5

共 42 条

[1] NK-LYSIN, A NOVEL EFFECTOR PEPTIDE OF CYTOTOXIC T-CELLS AND NK-CELLS - STRUCTURE AND CDNA CLONING OF THE PORCINE FORM, INDUCTION BY INTERLEUKIN-2, ANTIBACTERIAL AND ANTITUMOR-ACTIVITY [J].

ANDERSSON, M ;

GUNNE, H ;

AGERBERTH, B ;

BOMAN, A ;

BERGMAN, T ;

SILLARD, R ;

JORNVALL, H ;

MUTT, V ;

OLSSON, B ;

WIGZELL, H ;

DAGERLIND, A ;

BOMAN, HG ;

GUDMUNDSSON, GH .

EMBO JOURNAL, 1995, 14 (08) :1615-1625

[2] MRL/lpr CD4(-)CD8(-) and CD8(+) T cells, respectively, mediate Fas-dependent and perforin cytotoxic pathways [J].

Benihoud, K ;

Bonardelle, D ;

Bobe, P ;

Kiger, N .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (02) :415-420

[3]

Bonecini-Almeida MG, 1998, J IMMUNOL, V160, P4490

[4] KILLING OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY REACTIVE NITROGEN INTERMEDIATES PRODUCED BY ACTIVATED MURINE MACROPHAGES [J].

CHAN, J ;

XING, Y ;

MAGLIOZZO, RS ;

BLOOM, BR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) :1111-1122

[5] The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms [J].

Cooper, AM ;

DSouza, C ;

Frank, AA ;

Orme, IM .

INFECTION AND IMMUNITY, 1997, 65 (04) :1317-1320

[6]

DELIBERO G, 1988, EUR J IMMUNOL, V18, P59, DOI 10.1002/eji.1830180110

[7] INTERFERON-GAMMA-TREATED MURINE MACROPHAGES INHIBIT GROWTH OF TUBERCLE-BACILLI VIA THE GENERATION OF REACTIVE NITROGEN INTERMEDIATES [J].

DENIS, M .

CELLULAR IMMUNOLOGY, 1991, 132 (01) :150-157

[8]

Denkers EY, 1997, J IMMUNOL, V159, P1903

[9] PURIFIED PERFORIN INDUCES TARGET-CELL LYSIS BUT NOT DNA FRAGMENTATION [J].

DUKE, RC ;

PERSECHINI, PM ;

CHANG, S ;

LIU, CC ;

COHEN, JJ ;

YOUNG, JDE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1451-1456

[10] MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I-RESTRICTED T-CELLS ARE REQUIRED FOR RESISTANCE TO MYCOBACTERIUM-TUBERCULOSIS INFECTION [J].

FLYNN, JL ;

GOLDSTEIN, MM ;

TRIEBOLD, KJ ;

KOLLER, B ;

BLOOM, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :12013-12017

← 1 2 3 4 5 →