The complexity of mitogen-activated protein kinases (MAPKs) made simple

被引：356

作者：

Krishna, M. ^{[1
]}

Narang, H. ^{[1
]}

机构：

[1] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Bombay 400085, Maharashtra, India

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 22期

关键词：

Mitogen-activated protein kinase; activation; phosphorylation; specificity; ERK; p38; JNK;

D O I：

10.1007/s00018-008-8170-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mitogen-activated protein kinase (MAPK) pathways are known to be involved in various processes of growth, differentiation and cell death. In spite of their ubiquitous presence and seemingly enormous cross-talk with each other, their action is very specific. This review deals with various aspects of the three different MAPK pathways (ERK, p38 and JNK) and how their specificity is brought about.

引用

页码：3525 / 3544

页数：20

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