The many faces of β-TrCP E3 ubiquitin ligases:: reflections in the magic mirror of cancer

被引：275

作者：

Fuchs, SY

Spiegelman, VS

Kumar, KGS

机构：

[1] Univ Penn, Dept Anim Biol, Philadelphia, PA 19104 USA

[2] AMC, Canc Res Ctr, Lakewood, CO 80214 USA

来源：

ONCOGENE | 2004年 / 23卷 / 11期

关键词：

beta-TrCP; F-box; ubiquitin ligase; NF-kappa B; beta-catenin;

D O I：

10.1038/sj.onc.1207389

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFbeta-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying beta-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also discussed.

引用

页码：2028 / 2036

页数：9

共 97 条

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