Multivariate Activation and Connectivity Patterns Discriminate Speech Intelligibility in Wernicke's, Broca's, and Geschwind's Areas

被引:37
作者
Abrams, Daniel A. [1 ]
Ryali, Srikanth [1 ]
Chen, Tianwen [1 ]
Balaban, Evan [4 ]
Levitin, Daniel J. [4 ]
Menon, Vinod [1 ,2 ,3 ]
机构
[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Program Neurosci, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[4] McGill Univ, Dept Psychol, Montreal, PQ, Canada
基金
加拿大创新基金会; 美国国家科学基金会; 美国国家卫生研究院; 加拿大自然科学与工程研究理事会;
关键词
Angular gyrus; Auditory cortex; Broca's area; Inferior frontal gyrus; Speech perception; CONVERGING EVIDENCE; NEURAL MECHANISMS; SEMANTIC SYSTEM; AUDITORY-CORTEX; ANGULAR GYRUS; FMRI; LANGUAGE; BRAIN; COMPREHENSION; INFORMATION;
D O I
10.1093/cercor/bhs165
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The brain network underlying speech comprehension is usually described as encompassing fronto temporal parietal regions while neuroimaging studies of speech intelligibility have focused on a more spatially restricted network dominated by the superior temporal cortex. Here we use functional magnetic resonance imaging with a novel whole-brain multivariate pattern analysis (MVPA) to more fully characterize neural responses and connectivity to intelligible speech. Consistent with previous univariate findings, intelligible speech elicited greater activity in bilateral superior temporal cortex relative to unintelligible speech. However, MVPA identified a more extensive network that discriminated between intelligible and unintelligible speech, including left-hemisphere middle temporal gyrus, angular gyrus, inferior temporal cortex, and inferior frontal gyrus pars triangularis. These fronto temporal parietal areas also showed greater functional connectivity during intelligible, compared with unintelligible, speech. Our results suggest that speech intelligibly is encoded by distinct fine-grained spatial representations and within-task connectivity, rather than differential engagement or disengagement of brain regions, and they provide a more complete view of the brain network serving speech comprehension. Our findings bridge a divide between neural models of speech comprehension and the neuroimaging literature on speech intelligibility, and suggest that speech intelligibility relies on differential multivariate response and connectivity patterns in Wernicke's, Broca's, and Geschwind's areas.
引用
收藏
页码:1703 / 1714
页数:12
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