Ursolic acid enhances cyclooxygenases and tumor necrosis factor-α expression in mouse skin

被引：15

作者：

Ikeda, Y ^{[1
]}

Murakami, A ^{[1
]}

Nishizawa, T ^{[1
]}

Ohigashi, H ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Kyoto 6068502, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2006年 / 70卷 / 04期

关键词：

ursolic acid; inflammation; cyclooxygenase; tumor necrosis factor-alpha; 12-O-tetradecanoylphorbol-13-acetate;

D O I：

10.1271/bbb.70.1033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An anti-inflammatory triterpenoid, ursolic acid (UA), has recently been found unexpectedly to induce the release of a pro-inflammatory mediator in resting macrophages. In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-alpha, whereas its effect on tumor promotion was unclear.

引用

页码：1033 / 1037

页数：5

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