Characteristics of in-hospital onset ischemic stroke

Background and Purpose: The aim of the present study was to clarify the clinical characteristics of in-hospital onset stroke. Material and Methods: We analyzed 15,815 patients with acute brain infarction registered in the Japan Multicenter Stroke Investigators' Collaboration Q-MUSIC) registry. Results:The in-hospital onset group included 694 (4.4%) patients and the out-of-hospital group included 15,121 (95.6%) patients. Atrial fibrillation (AF) was more common in the in-hospital onset group (34.6%) than in the out-of-hospital group (20.4%, p < 0.001). The admission NIHSS score (median, in-hospital 13 vs. out-of-hospital 5, p < 0.0001) and the mortality rate at discharge were higher in the in-hospital group than in the out-of-hospital group (in-hospital 19.2% vs. out-of-hospital 6.8%, p < 0.0001). On multivariate logistic regression analyses, female gender (OR 1.1, 95% Cl 1.1-1.3), older age (OR 1.0, 95% Cl 1.02-1.03), AF (OR 4.4,95% Cl 4.0-4.8), history of stroke (OR 1.3,95% Cl 1.2-1.4) and in-hospital stroke onset (OR 3.3, 95 %CI 2.7-3.9) were independent factors associated with severe stroke (NIHSS score >= 11), and older age (OR 1.03,95% Cl 1.02-1.04), the presence of AF (OR 1.21, 95% Cl 1.0-1.5), in-hospital stroke onset (OR 1.01, 95% Cl 1.01-1.02) and NIHSS score at initial evaluation (OR 1.15, 95% Cl 1.14-1.17) were independent factors associated with death at discharge. Conclusion: In-hospital stroke onset was not uncommon. The neurological deficits in patients with in-hospital onset stroke were severer and the outcome was worse than in those with out-of-hospital stroke. Therefore, a strategy to reduce in-hospital stroke onset should be implemented. Copyright (c) 2006 S. Karger AG, Basel.