共 16 条
Antibodies against glutathione S-transferase T1 (GSTT1) in patients with de novo immune hepatitis following liver transplantation
被引:89
作者:

Aguilera, I
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain

Wichmann, I
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain

Sousa, JM
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain

Bernardos, A
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain

Franco, E
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain

García-Lozano, JR
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain

Núñez-Roldán, A
论文数: 0 引用数: 0
h-index: 0
机构: Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain
机构:
[1] Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Inmunol, Seville 41013, Spain
[2] Hosp Univ Virgen Rocio, Serv Andaluz Salud, Serv Aparato Digest Unidad Trasplante Hepat, Seville 41013, Spain
关键词:
GSTT1;
immune hepatitis;
liver transplantation;
D O I:
10.1046/j.1365-2249.2001.01682.x
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Four patients of 283 liver-transplant recipients (1.4%) developed de novo immune-mediated hepatitis approximately 2 years after transplantation. Antibodies showing an unusual liver/kidney cytoplasmic staining pattern were detected in the sera of all four patients and one of them was used to screen a human liver cDNA expression library with the aim of identifying the antigenic target of these newly developed antibodies. After cloning and sequencing the gene, it was identified as the gene encoding the glutathion-S-transferase T1 (GSTT1), a 29-kD molecular weight protein, expressed abundantly in liver and kidney. Sera from the other three patients also contained anti-GSTT1 antibodies, two of them demonstrated by immunoblot analysis against the recombinant antigen and the other, which was negative by immunoblot, gave a positive reaction when used directly to screen the same library, suggesting it to be directed to a conformational epitope. The GSTT1 enzyme is the product of a single polymorphic gene that is absent from 20% of the Caucasian population. When we analysed the GSTT1 genotype of the four patients described above, we found that this gene is absent from all of them. Three donor paraffin embedded DNA samples were available and were shown to be positive for GSSTT1 genotype. In accordance with these results, we suggest that this form of post-transplant de novo immune hepatitis, that has been reported as autoimmune hepatitis by others, could be the result of an antigraft reaction in individuals lacking the GSTT1 phenotype, in which the immune system recognizes the GSTT1 protein as a non-self antigen, being the graft dysfunction not the result of an autoimmune reaction, but the consequence of an alo-reactive immune response.
引用
收藏
页码:535 / 539
页数:5
相关论文
共 16 条
[1]
International Autoimmune Hepatitis Group Report:: review of criteria for diagnosis of autoimmune hepatitis
[J].
Alvarez, E
;
Berg, PA
;
Bianchi, FB
;
Bianchi, L
;
Burroughs, AK
;
Cancado, EL
;
Chapman, RW
;
Cooksley, WGE
;
Czaja, AJ
;
Desmet, VJ
;
Donaldson, RT
;
Eddleston, ALWF
;
Fainboim, L
;
Heathcote, J
;
Homberg, JC
;
Hoofnagle, JH
;
Kakumu, S
;
Krawitt, EL
;
Mackay, IR
;
MacSween, RNM
;
Maddrey, WC
;
Manns, MP
;
McFarlane, IG
;
zum Büschenfelde, KHM
;
Mieli-Vergani, G
;
Nakanuma, Y
;
Nishioka, M
;
Penner, E
;
Porta, G
;
Portmann, BC
;
Reed, WD
;
Rodes, J
;
Schalm, SW
;
Scheuer, PJ
;
Schrumpf, E
;
Seki, T
;
Toda, G
;
Tsuji, T
;
Tygstrup, N
;
Vergani, D
;
Zeniya, M
.
JOURNAL OF HEPATOLOGY,
1999, 31 (05)
:929-938

Alvarez, E
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Berg, PA
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Bianchi, FB
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Bianchi, L
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Burroughs, AK
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Cancado, EL
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Chapman, RW
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Cooksley, WGE
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Czaja, AJ
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Desmet, VJ
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Donaldson, RT
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Eddleston, ALWF
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Fainboim, L
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Heathcote, J
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Homberg, JC
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Hoofnagle, JH
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Kakumu, S
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Krawitt, EL
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Mackay, IR
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

MacSween, RNM
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Maddrey, WC
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Manns, MP
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

McFarlane, IG
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

zum Büschenfelde, KHM
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Mieli-Vergani, G
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Nakanuma, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Nishioka, M
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Penner, E
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Porta, G
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Portmann, BC
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Reed, WD
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Rodes, J
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Schalm, SW
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Scheuer, PJ
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Schrumpf, E
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Seki, T
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Toda, G
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Tsuji, T
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Tygstrup, N
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Vergani, D
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England

Zeniya, M
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England Kings Coll Hosp London, Inst Liver Studies, London SE5 9RS, England
[2]
A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX
[J].
DEVEREUX, J
;
HAEBERLI, P
;
SMITHIES, O
.
NUCLEIC ACIDS RESEARCH,
1984, 12 (01)
:387-395

DEVEREUX, J
论文数: 0 引用数: 0
h-index: 0

HAEBERLI, P
论文数: 0 引用数: 0
h-index: 0

SMITHIES, O
论文数: 0 引用数: 0
h-index: 0
[3]
PRESENCE OF ANTIBODIES TO DIFFERENT SUBUNITS OF REPLICATION PROTEIN-A IN AUTOIMMUNE SERA
[J].
GARCIALOZANO, R
;
GONZALEZESCRIBANO, F
;
SANCHEZROMAN, J
;
WICHMANN, I
;
NUNEZROLDAN, A
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1995, 92 (11)
:5116-5120

GARCIALOZANO, R
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN

GONZALEZESCRIBANO, F
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN

SANCHEZROMAN, J
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN

WICHMANN, I
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN

NUNEZROLDAN, A
论文数: 0 引用数: 0
h-index: 0
机构:
HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN HOSP UNIV VIRGEN DEL ROCIO, SERV ANDALUZ SALUD, SERV IMMUNOL, E-41013 SEVILLE, SPAIN
[4]
Glutathione S-transferase polymorphisms and their biological consequences
[J].
Hayes, JD
;
Strange, RC
.
PHARMACOLOGY,
2000, 61 (03)
:154-166

Hayes, JD
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Dundee, Ninewells Hosp & Med Sch, Ctr Biomed Res, Dundee DD1 9SY, Scotland Univ Dundee, Ninewells Hosp & Med Sch, Ctr Biomed Res, Dundee DD1 9SY, Scotland

Strange, RC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Dundee, Ninewells Hosp & Med Sch, Ctr Biomed Res, Dundee DD1 9SY, Scotland
[5]
Development of autoimmune hepatitis following liver transplantation for primary biliary cirrhosis
[J].
Jones, DEJ
;
James, OFW
;
Portmann, B
;
Burt, AD
;
Williams, R
;
Hudson, M
.
HEPATOLOGY,
1999, 30 (01)
:53-57

Jones, DEJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle, Kings Coll Hosp, Liver Res Ctr, London, England

James, OFW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle, Kings Coll Hosp, Liver Res Ctr, London, England

Portmann, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle, Kings Coll Hosp, Liver Res Ctr, London, England

Burt, AD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle, Kings Coll Hosp, Liver Res Ctr, London, England

Williams, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle, Kings Coll Hosp, Liver Res Ctr, London, England

Hudson, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle, Kings Coll Hosp, Liver Res Ctr, London, England
[6]
De-novo autoimmune hepatitis after liver transplantation
[J].
Kerkar, N
;
Hadzic, N
;
Davies, ET
;
Portmann, B
;
Donaldson, PT
;
Rela, M
;
Heaton, ND
;
Vergani, D
;
Mieli-Vergani, G
.
LANCET,
1998, 351 (9100)
:409-413

Kerkar, N
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Hadzic, N
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Davies, ET
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Portmann, B
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Donaldson, PT
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Rela, M
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Heaton, ND
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Vergani, D
论文数: 0 引用数: 0
h-index: 0
机构: Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England

Mieli-Vergani, G
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England Kings Coll Hosp London, Dept Child Hlth, London SE5 9PJ, England
[7]
Glutathione S-transferase as a major autoantigen in anti SLA-positive autoimmune hepatitis
[J].
Klein, R
;
Berg, PA
.
GASTROENTEROLOGY,
1999, 116 (04)
:1015-1016

Klein, R
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Internal Med, D-72074 Tubingen, Germany Univ Tubingen, Dept Internal Med, D-72074 Tubingen, Germany

Berg, PA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Internal Med, D-72074 Tubingen, Germany Univ Tubingen, Dept Internal Med, D-72074 Tubingen, Germany
[8]
CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4
[J].
LAEMMLI, UK
.
NATURE,
1970, 227 (5259)
:680-+

LAEMMLI, UK
论文数: 0 引用数: 0
h-index: 0
[9]
Mammalian class theta GST and differential susceptibility to carcinogens: a review
[J].
Landi, S
.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH,
2000, 463 (03)
:247-283

Landi, S
论文数: 0 引用数: 0
h-index: 0
机构:
US EPA, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA US EPA, Div Environm Carcinogenesis, Res Triangle Pk, NC 27711 USA
[10]
Autoimmune hepatitis
[J].
Obermayer-Straub, P
;
Strassburg, CP
;
Manns, MP
.
JOURNAL OF HEPATOLOGY,
2000, 32
:181-197

Obermayer-Straub, P
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Dept Gastroenterol & Hepatol, D-30625 Hannover, Germany Hannover Med Sch, Dept Gastroenterol & Hepatol, D-30625 Hannover, Germany

Strassburg, CP
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Dept Gastroenterol & Hepatol, D-30625 Hannover, Germany Hannover Med Sch, Dept Gastroenterol & Hepatol, D-30625 Hannover, Germany

Manns, MP
论文数: 0 引用数: 0
h-index: 0
机构:
Hannover Med Sch, Dept Gastroenterol & Hepatol, D-30625 Hannover, Germany Hannover Med Sch, Dept Gastroenterol & Hepatol, D-30625 Hannover, Germany