Cytokine and Chemokine Levels in Patients Infected With the Novel Avian Influenza A (H7N9) Virus in China

被引：85

作者：

Chi, Ying ^{[1
]}

Zhu, Yefei ^{[2
]}

Wen, Tian ^{[1
]}

Cui, Lunbiao ^{[1
]}

Ge, Yiyue ^{[1
]}

Jiao, Yongjun ^{[1
]}

Wu, Tao ^{[1
]}

Ge, Aihua ^{[2
]}

Ji, Hong ^{[2
]}

Xu, Ke ^{[2
]}

Bao, Changjun ^{[2
]}

Zhu, Zheng ^{[1
]}

Qi, Xian ^{[2
]}

Wu, Bin ^{[2
]}

Shi, Zhiyang ^{[1
]}

Tang, Fenyang ^{[2
]}

Xing, Zheng ^{[3
]}

Zhou, Minghao ^{[2
]}

机构：

[1] Jiangsu Prov Ctr Dis Control & Prevent, Minist Hlth, Inst Pathogen Microbiol, Key Lab Enter Pathogen Microbiol, Nanjing 210009, Jiangsu, Peoples R China

[2] Jiangsu Prov Ctr Dis Control & Prevent, Dept Acute Infect Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China

[3] Nanjing Univ, Sch Med, Nanjing 210008, Jiangsu, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2013年 / 208卷 / 12期

关键词：

H7N9 avian influenza; cytokine; chemokine; H5N1; VIRUSES; RESPONSES; DISEASE;

D O I：

10.1093/infdis/jit440

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Th17 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.

引用

页码：1962 / 1967

页数：6

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