Plasma endothelin-1 levels in patients with aldosterone-producing adenoma and pheochromocytoma

被引：15

作者：

Letizia, C ^{[1
]}

DeToma, G ^{[1
]}

Cerci, S ^{[1
]}

Scuro, L ^{[1
]}

DeCiocchis, A ^{[1
]}

DAmbrosio, C ^{[1
]}

Massa, R ^{[1
]}

Cavallaro, A ^{[1
]}

Scavo, D ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,CLIN RADIOL,ROME,ITALY

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 1996年 / 18卷 / 07期

关键词：

aldosterone-producing adenoma; endothelin-1; essential hypertension; pheochromocytoma;

D O I：

10.3109/10641969609097908

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the study was to evaluate possible changes of plasma endothelin-1 levels (ET-1) in patients with hypertension secondary to primary aldosteronism and pheochromocytoma. We enrolled in the study: 12 patients affected by aldosterone-producing adenoma (5 M and 7 W; mean age 42.1 +/- 17.2 years); 8 patients with pheochromocytoma (5 M, 3 W; mean age 36.2 +/- 17.1 years); 15 patients with essential hypertension (9 M, 6 W; mean age 48.5+/-10 years). We also enrolled a normal control group (8 M, 12 W; mean age 34.2 +/- 11 years). The mean plasma ET-1 concentrations in patients with pheochromocytoma were significantly higher (23.9 +/- 5.2 pg/ml) than those in normal subjects (7.3 +/- 1.9 pg/ml), in patients with primary aldosteronism (12.1 +/- 3.8 pg/ml) and in patients with essential hypertension (9.2 +/- 3 pg/ml); p < 0.001, respectively. The present investigation demonstrates that in human adrenal hypertension patients with pheochromocytoma have increased circulating ET-1 levels respect to patients with aldosterone-producing adenoma.

引用

页码：921 / 931

页数：11

共 31 条

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