Phagocytosis Independent Extracellular Nanoparticle Clearance by Human Immune Cells

被引:146
作者
Bartneck, Matthias [1 ]
Keul, Heidrun A. [3 ,4 ]
Zwadlo-Klarwasser, Gabriele [1 ,2 ]
Groll, Juergen [3 ,4 ]
机构
[1] Rhine Westphalia Inst Technol RWTH, Interdisciplinary Ctr Clin Res IZKF BioMAT, Aachen, Germany
[2] Rhine Westphalia Inst Technol RWTH, Univ Hosp, Dept Dermatol, Aachen, Germany
[3] Rhein Westfal TH Aachen, DWI eV, Aachen, North Rhine Wes, Germany
[4] Rhein Westfal TH Aachen, Inst Tech & Macromol Chem, Aachen, North Rhine Wes, Germany
关键词
Gold nanorods; human immune cells; nanoparticle clearance; BLOOD MONOCYTES; DENDRITIC CELLS; GOLD NANORODS; MAST-CELLS; MATURATION; EVOLUTION; VIRUS;
D O I
10.1021/nl902830x
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
It has recently been discovered that human immune cells, especially neutrophil granulocytes. form neutrophil extracellular traps (NETS) that abolish pathogens. Our study provides evidence that extracellular traps formed by neutrophils, monocytes and macrophages act as physical barriers for nanoparticles, thus presenting a new nanomaterial clearance mechanism of the human immune system. While particle shape is of minor importance, positive charges significantly enhance particle trapping.
引用
收藏
页码:59 / 63
页数:5
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