ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells

被引:277
作者
Smirnova, E
Goldberg, EB
Makarova, KS
Lin, L
Brown, WJ
Jackson, CL [1 ]
机构
[1] NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA
[2] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA
[3] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA
关键词
adipose triglyceride lipase; lipid droplet; adiposome; patatin domain; adiposome triglyceride lipase;
D O I
10.1038/sj.embor.7400559
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lipid droplets (LDs), also called adiposomes, are found in many eukaryotic cells, and are highly upregulated in lipid-storage cells, such as adipocytes. The mechanism by which adiposomes and their component neutral lipids are degraded is an important health issue with the rapidly spreading epidemic of obesity. Recently, a novel triglyceride lipase (adipose triglyceride lipase (ATGL)) that catalyses the initial step in triglyceride hydrolysis in adipocyte LDs was identified. Here, we show that ATGL also functions in non-adipocyte cells, and has an important role in LD degradation in these cells. Overexpression of wild-type ATGL causes a marked decrease in LD size, whereas a catalytically inactive mutant retains the ability to localize to LDs, but is unable to decrease their size. Depletion of ATGL by RNA interference leads to a significant increase in the size of LDs. These results show that ATGL has an important role in LD/adiposome turnover in mammalian cells.
引用
收藏
页码:106 / 113
页数:8
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