Efficient construction of indole rings from 2-ethynylaniline derivatives catalyzed by copper(II) salts and its application to the tandem cyclization reactions

被引：111

作者：

Hiroya, K ^{[1
]}

Itoh, S ^{[1
]}

Ozawa, M ^{[1
]}

Kanamori, Y ^{[1
]}

Sakamoto, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 07期

关键词：

indole; cyclization reaction; copper(II) trifluoromethanesulfonate; copper(II) acetate; 2-ethynylaniline;

D O I：

10.1016/S0040-4039(01)02396-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient cyclization reactions of the N-methanesulfonyl or N-ethoxycarbonyl derivatives of 2-ethynylanilines. functionalized on the benzene ring and/or the acetylene terminal into indoles catalyzed by either Cu(OTf)(2) or Cu(OAc)(2) are accomplished. The application of this reaction to the tandem cyclization reaction is also described. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1277 / 1280

页数：4

共 25 条

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