Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues

被引：6

作者：

McGuigan, C

Carangio, A

Snoeck, R

Andrei, G

De Clercq, E

Balzarini, J

机构：

[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales

[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 1-2期

关键词：

VZV; bicyclic nucleoside analogues; Y-OH;

D O I：

10.1081/NCN-120027813

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 3'-fluoro analogues of recently discovered highly potent anti-VZV furanopyrimidine deoxynucleosides (BCNAs) is herein reported, for both the alkyl and alkylphenyl series. The compounds are tested against a range of herpes viruses and display poor activity, strongly supporting the notion of the importance of the presence of a 3'-OH for antiviral activity.

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页码：1 / 5

页数：5

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