C-Jun is critical for the progression of osteosarcoma:: Proof in an orthotopic spontaneously metastasizing model

被引：28

作者：

Dass, Crispin R. ^{[1
,2
]}

Khachigian, Levon M. ^{[3
,4
]}

Choong, Peter F. M. ^{[1
,2
,5
]}

机构：

[1] St Vincents Hosp, Dept Orthopaed, Melbourne, Vic 3065, Australia

[2] Univ Melbourne, St Vincents Hosp, Dept Surg, Melbourne, Vic 3010, Australia

[3] Univ New S Wales, Ctr Vasc Res, Sydney, NSW 2052, Australia

[4] Prince Wales Hosp, Sydney, NSW, Australia

[5] Peter MacCallum Canc Inst, Sarcoma Serv, Melbourne, Vic 3000, Australia

来源：

MOLECULAR CANCER RESEARCH | 2008年 / 6卷 / 08期

关键词：

D O I：

10.1158/1541-7786.MCR-08-0036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma. DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation-mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL pathway. Clinically, knockdown of c-Jun with DNAzymes may proffer an improved treatment outcome for these tumors originating in bone.

引用

页码：1289 / 1292

页数：4

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