Solid phase synthesis of spiroindoline

被引：37

作者：

Cheng, Y

Chapman, KT

机构：

[1] Automated Sythesis Group, Dept. of Molec. Des. and Diversity, Merck Research Laboratories, Rahway

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 09期

关键词：

COMBINATORIAL TECHNOLOGIES; DRUG DISCOVERY;

D O I：

10.1016/S0040-4039(97)00139-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for solid phase synthesis of spiroindolines using the Fischer indole reaction is described. Various arylhydrazines react cleanly with polymer bound piperidine-4-carboxaldehyde in TFA/CH2Cl2. The products are isolated in good yields and high purity. (C) 1997 Elsevier Science Ltd.

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页码：1497 / 1500

页数：4

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