Microstructure of the ligament-to-bone attachment complex in the human knee joint

被引:26
作者
Subit, Damien [1 ,2 ]
Masson, Catherine [1 ]
Brunet, Christian [1 ]
Chabrand, Patrick [3 ,4 ]
机构
[1] Fac Med Secteur Nord Marseille, Lab Biomecan Appl, F-13916 Marseille 20, France
[2] Lab Mecan & Acoust, F-13402 Marseille 20, France
[3] CNRS, F-13288 Marseille, France
[4] Univ Mediterranee, Lab Aerodynam & Biomecan Mouvement, F-13288 Marseille, France
关键词
Ligament-to-bone attachment; Fibrocartilage; Microstructure; Knee; Collagen fibres; Mechanical function;
D O I
10.1016/j.jmbbm.2008.02.002
中图分类号
R318 [生物医学工程];
学科分类号
0831 [生物医学工程];
摘要
Clinical and experimental studies have shown that injuries in the human knee ligaments occur in the ligament midsubstance, at the transition between bone and ligament, and in the bone in the vicinity of the ligament-to-bone attachment site. Whereas ligament and bone have been thoroughly described, the way they connect to each other remains unclear. The goal of this study is to provide a description of the microstructure of the ligament-to-bone insertion, with the view of providing a mechanical model capable of predicting the injuries that occur at this insertion. The preparatory literature review showed that there was no description of the insertion microstructure for the human ligaments. The results found for human tendons and animal tendons/ligaments were used to lead the histological and electron - scanning and transmission - microscopy analysis. The posterior cruciate ligament (PCL), and the lateral collateral ligament (LCL) were sampled from one post mortem human subject. Slices were cut along the longitudinal direction of the ligaments, following the fibers direction. The histology analysis showed that the insertion has the same structure as reported in the literature: it is made of a mineralization front between calcified and uncalcified fibrocartilage, which is not crossed by the ligament fibers. The transmission electron microscopy analysis of the calcified fibrocartilage revealed a collagenous structure which has a direction drastically different from the direction of the ligament fibers. The mechanical function of the insertion was discussed and combined with the histological findings to hypothesize the microstructure of the insertion. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:360 / 367
页数:8
相关论文
共 37 条
[1]
[Anonymous], 1970, STRENGTH BIOL MAT
[2]
[Anonymous], PHYSL JOINTS
[3]
[Anonymous], [No title captured]
[4]
A visco-hyperelastic model with damage for the knee ligaments under dynamic constraints [J].
Arnoux, P.J. ;
Chabrand, P. ;
Jean, M. ;
Bonnoit, J. .
Computer Methods in Biomechanics and Biomedical Engineering, 2002, 5 (02) :167-174
[5]
Arnoux P.J., 2000, THESIS U MEDITERRANE
[6]
ARNOUX PJ, 2005, REV EUROP ELEMENTS F, V14, P577
[7]
BENJAMIN M, 1991, J ANAT, V177, P127
[8]
BENJAMIN M, 1986, J ANAT, V149, P89
[9]
Benjamin M, 1995, J ANAT, V187, P625
[10]
The skeletal attachment of tendons - tendon 'entheses' [J].
Benjamin, M ;
Kumai, T ;
Milz, S ;
Boszczyk, BM ;
Boszczyk, AA ;
Ralphs, JR .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY, 2002, 133 (04) :931-945