Application of hyaluronic acid as carriers in drug delivery

被引：403

作者：

Huang, Gangliang ^{[1
]}

Huang, Hualiang ^{[2
]}

机构：

[1] Chongqing Normal Univ, Act Carbohydrate Res Inst, Chongqing 401331, Peoples R China

[2] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China

来源：

DRUG DELIVERY | 2018年 / 25卷 / 01期

关键词：

Hyaluronic acid; derivatives; drug carriers; drug delivery; tumor targeting; TUMOR-TARGETED DELIVERY; CONTROLLED-RELEASE; SUSTAINED-RELEASE; IN-VIVO; PACLITAXEL; INSULIN; NANOPARTICLES; FORMULATION; CARCINOMAS; HYDROGELS;

D O I：

10.1080/10717544.2018.1450910

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Hyaluronic acid has good biocompatibility, biodegradability, and nonimmunogenicity. In addition, it has the ability to recognize specific receptors that are overexpressed on the surface of tumor cells, and cancer drugs can be targeted to the tumor cells to better kill them. Therefore, hyaluronic acid has attracted much attention as drug delivery vehicle. Herein, the application of hyaluronic acid as carrier in drug delivery was analyzed and summarized in detail. It showed that hyaluronic acid would have broad prospects for drug delivery.

引用

收藏

页码：766 / 772

页数：7

相关论文

共 53 条

[1]

Interaction of CD44 with different forms of hyaluronic acid. Its role in adhesion and migration of tumor cells [J].

Alaniz, L ;

Cabrera, PV ;

Blanco, G ;

Ernst, G ;

Rimoldi, G ;

Alvarez, E ;

Hajos, SE .

CELL COMMUNICATION AND ADHESION, 2002, 9 (03) :117-130

[2]

Synthesis of novel polyampholyte comb-type copolymers consisting of a poly(L-lysine) backbone and hyaluronic acid side chains for a DNA carrier [J].

Asayama, S ;

Nogawa, M ;

Takei, Y ;

Akaike, T ;

Maruyama, A .

BIOCONJUGATE CHEMISTRY, 1998, 9 (04) :476-481

[3]

Hyaluronic acid: Targeting immune modulatory components of the extracellular matrix in atherosclerosis [J].

Bot, Pieter T. ;

Hoefer, Imo E. ;

Piek, Jan J. ;

Pasterkamp, Gerard .

CURRENT MEDICINAL CHEMISTRY, 2008, 15 (08) :786-791

[4]

Self-Defensive Biomaterial Coating Against Bacteria and Yeasts: Polysaccharide Multilayer Film with Embedded Antimicrobial Peptide [J].

Cado, G. ;

Aslam, R. ;

Seon, L. ;

Garnier, T. ;

Fabre, R. ;

Parat, A. ;

Chassepot, A. ;

Voegel, J. -C. ;

Senger, B. ;

Schneider, F. ;

Frere, Y. ;

Jierry, L. ;

Schaaf, P. ;

Kerdjoudj, H. ;

Metz-Boutigue, M. -H. ;

Boulmedais, F. .

ADVANCED FUNCTIONAL MATERIALS, 2013, 23 (38) :4801-4809

[5]

Hyaluronic Acid-Based Drug Conjugates: State-of-the-Art and Perspectives [J].

Chen, Bo ;

Miller, Robert J. ;

Dhal, Pradeep K. .

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2014, 10 (01) :4-16

[6]

Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel [J].

Cho, Hyun-Jong ;

Yoon, Hong Yeol ;

Koo, Heebeom ;

Ko, Seung-Hak ;

Shim, Jae-Seong ;

Lee, Ju-Hee ;

Kim, Kwangmeyung ;

Kwon, Ick Chan ;

Kim, Dae-Duk .

BIOMATERIALS, 2011, 32 (29) :7181-7190

[7]

PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo [J].

Choi, Ki Young ;

Min, Kyung Hyun ;

Yoon, Hong Yeol ;

Kim, Kwangmeyung ;

Park, Jae Hyung ;

Kwon, Ick Chan ;

Choi, Kuiwon ;

Jeong, Seo Young .

BIOMATERIALS, 2011, 32 (07) :1880-1889

[8]

Controlled release systems for insulin delivery [J].

Chu, LY .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2005, 15 (09) :1147-1155

[9]

Controlled release of plasmid DNA from photo-cross-linked pluronic hydrogels [J].

Chun, KW ;

Lee, JB ;

Kim, SH ;

Park, TG .

BIOMATERIALS, 2005, 26 (16) :3319-3326

[10]

Inhibition of hepatocellular carcinomas in vitro and hepatic metastases in vivo in mice by the histone deacetylase inhibitor HA-But [J].

Coradini, D ;

Zorzet, S ;

Rossin, R ;

Scarlata, I ;

Pellizzaro, C ;

Turrin, C ;

Bello, M ;

Cantoni, S ;

Speranza, A ;

Sava, G ;

Mazzi, U ;

Perbellini, A .

CLINICAL CANCER RESEARCH, 2004, 10 (14) :4822-4830

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