Strontium modified biocements with zero order release kinetics

被引：74

作者：

Alkhraisat, Mohammad Hamdan ^{[2
,3
]}

Moseke, Claus ^{[1
]}

Blanco, Luis ^{[3
]}

Barralet, Jake E. ^{[4
]}

Lopez-Carbacos, Enrique ^{[2
]}

Gbureck, Uwe ^{[1
]}

机构：

[1] Univ Wurzburg, Dept Funct Mat Med & Dent, D-97070 Wurzburg, Germany

[2] UCM, Fac Farm, Dept Quim Fis 2, Madrid 28040, Spain

[3] UCM, Fac Odontol, Dept Estomatol 4, Madrid 28040, Spain

[4] McGill Univ, Fac Dent, Montreal, PQ H3A 2B2, Canada

来源：

BIOMATERIALS | 2008年 / 29卷 / 35期

关键词：

Brushite; Monetite; Calcium phosphate bone cement; Strontium substitution; Osteoblast; Biocompatibility;

D O I：

10.1016/j.biomaterials.2008.08.026

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Strontium-substituted beta-TCP with the general formula Ca(3-x)Srx(PO4)(2) (0 < x < 1) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with acidic monocalcium phosphate monohydrate (MCPM) to form a cementitious matrix of secondary calcium phosphates. The use of Sr-substituted beta-TCP as a reactant not only induced strontium substitution in the setting products but surprisingly it also favoured the formation of monetite (CaHPO4) as setting product, whereas Sr-free cements set to brushite (CaHPO4 center dot 2H(2)O). Release experiments under dynamic conditions for up to 15 days revealed the release of Sr2+ ions at dose ranges of 12-30 ppm with zero order release kinetic. Cement cytocompatibility was investigated by culturing human osteoblast cell line hFOB1.19 on cement surfaces whereas Sr-containing cements were as good as Sr-free cements in providing a template for cell growth and function. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4691 / 4697

页数：7

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