Association between interleukin-6 and carotid atherosclerosis in hemodialysis patients

被引:78
作者
Kato, A
Odamaki, M
Takita, T
Maruyama, Y
Kumagai, H
Hishida, A
机构
[1] Univ Shizuoka, Sch Food & Nutr Sci, Dept Clin Nutr, Hamamatsu, Shizuoka, Japan
[2] Hamamatsu Univ Sch Med, Maruyama Hosp, Dept Med 1, Hamamatsu, Shizuoka 4313192, Japan
关键词
Chlamydia pneumoniae; atherosclerosis; IL-6; soluble TNF receptor; hemodialysis; carotid artery; uremia; cardiovascular disease;
D O I
10.1046/j.1523-1755.2002.00215.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background. Interleukin-6 (IL-6) is associated with cardiovascular complications in general subjects. Although blood IL-6 is greatly elevated in hemodialysis (HD) patients, the role of IL-6 in the advance of atherosclerosis remains to be determined. Methods. We conducted a cross-sectional study to investigate the relationship between circulating IL-6 and carotid atherosclerotic changes in 156 HD patients (age 58 +/- 1 years; time on HD treatment 13 +/- 1 years; 97 males and 59 females). Serum IL-6, IgG and IgA titers of Chlamydia pneumoniae antibodies, the intima-media thickness (IMT) and the cross-sectional intima-media area (IMarea) of the carotid arteries were measured by ultrasonography in each patient. Results. Serum IL-6 levels were significantly higher in HD patients (2.04 +/- 0.16 pg/mL) compared to normal age-matched control subjects (0.31 +/- 0.06 pg/mL, N = 24). Circulating log IL-6 levels were positively correlated with IMT (r = 0.278, P < 0.01) and IMarea (r = 0.344, P < 0.01), respectively. A stepwise multiple regression analysis revealed that IL-6 became significant predictors for IMT and IMarea but not for aortic wall calcification at L-2/3 vertebrae. Serum log IL-6 was significantly correlated with IgG (r = 0.277, P < 0.01) and IgA titers of anti-Chlamydia antibodies (r = 0.192, P < 0.02). Serum IgA anti-Chlamydia titers were also correlated with the maximal diameter of carotid plaque (r = 0.293, P < 0.04). Conclusions. These findings suggested that IL-6 is associated with the severity of carotid atherosclerosis in HD patients. Persistent chronic chlamydial infection may be related, in part, to the advance of carotid plaque enlargement in dialysis patients.
引用
收藏
页码:1143 / 1152
页数:10
相关论文
共 53 条
[1]   Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events [J].
Biasucci, LM ;
Liuzzo, G ;
Fantuzzi, G ;
Caligiuri, G ;
Rebuzzi, AG ;
Ginnetti, F ;
Dinarello, CA ;
Maseri, A .
CIRCULATION, 1999, 99 (16) :2079-2084
[2]   Increased levels of soluble tumor necrosis factor receptors in atherosclerosis: No clear relationship with levels of tumor necrosis factor [J].
Blann, AD ;
McCollum, CN .
INFLAMMATION, 1998, 22 (05) :483-491
[3]   Interleukin-6 predicts hypoalbuminemia, hypocholesterolemia, and mortality in hemodialysis patients [J].
Bologa, RM ;
Levine, DM ;
Parker, TS ;
Cheigh, JS ;
Serur, D ;
Stenzel, KH ;
Rubin, AL .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1998, 32 (01) :107-114
[4]   ARTERIAL-WALL THICKNESS IS ASSOCIATED WITH PREVALENT CARDIOVASCULAR-DISEASE IN MIDDLE-AGED ADULTS - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY [J].
BURKE, GL ;
EVANS, GW ;
RILEY, WA ;
SHARRETT, AR ;
HOWARD, G ;
BARNES, RW ;
ROSAMOND, W ;
CROW, RS ;
RAUTAHARJU, PM ;
HEISS, G .
STROKE, 1995, 26 (03) :386-391
[5]   The association of plasma IL-6 levels with functional disability in community-dwelling elderly [J].
Cohen, HJ ;
Pieper, CF ;
Harris, T ;
Rao, KMK ;
Currie, MS .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1997, 52 (04) :M201-M208
[6]   DEFECTIVE INFLAMMATORY RESPONSE IN INTERLEUKIN 6-DEFICIENT MICE [J].
FATTORI, E ;
CAPPELLETTI, M ;
COSTA, P ;
SELLITTO, C ;
CANTONI, L ;
CARELLI, M ;
FAGGIONI, R ;
FANTUZZI, G ;
GHEZZI, P ;
POLI, V .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1243-1250
[7]  
Girndt M, 1998, J AM SOC NEPHROL, V9, P1689
[8]   Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly [J].
Harris, TB ;
Ferrucci, L ;
Tracy, RP ;
Corti, MC ;
Wacholder, S ;
Ettinger, WH ;
Heimovitz, H ;
Cohen, HJ ;
Wallace, R .
AMERICAN JOURNAL OF MEDICINE, 1999, 106 (05) :506-512
[9]   APPLICATION OF FRIEDEWALD LDL-CHOLESTEROL ESTIMATION FORMULA TO SERUM-LIPIDS IN THE JAPANESE POPULATION [J].
HATA, Y ;
NAKAJIMA, K .
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1986, 50 (12) :1191-1200
[10]   C-reactive protein and chronic Chlamydia pneumoniae infection -: long-term predictors for cardiovascular disease and survival in patients on peritoneal dialysis [J].
Haubitz, M ;
Brunkhorst, R .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (04) :809-815