Kinetic analysis of diamine-catalyzed RNA hydrolysis

被引:61
作者
Komiyama, M
Yoshinari, K
机构
[1] Department of Chemistry, Graduate School of Engineering, University of Tokyo, Hongo
[2] Natl. Inst. Biosci./Hum. Technology, MITI
关键词
D O I
10.1021/jo961935u
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The catalysis of various amines for the hydrolysis of RNA has been kinetically investigated, and the catalytic rate constants for each of the ionic states of these amines are determined. Ethylenediamine and 1,3-propanediamine are highly active under the physiological conditions, mainly because they preferentially take the catalytically active monocationic forms. The catalysis of these diamines is further promoted by the intramolecular acid-base cooperation of the neutral amine and the ammonium ion. In contrast, monoamines overwhelmingly exist at pH 7 as the inactive cations. Potential application of the catalysis by the diamines and the related oligoamines is discussed.
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页码:2155 / 2160
页数:6
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