Design, synthesis and antibacterial activity of novel actinonin derivatives containing benzimidazole heterocycles

被引：29

作者：

Zhang, Datong ^{[1
]}

Wang, Zongheng ^{[2
]}

Xu, Weiren ^{[3
]}

Sun, Fanggang ^{[1
]}

Tang, Lida ^{[3
]}

Wang, Jianwu ^{[1
]}

机构：

[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China

[2] Shandong Univ, Sch Life Sci, Jinan 250100, Shandong, Peoples R China

[3] Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 05期

关键词：

Actinonin derivatives; Benzimidazole; Synthesis; Antibacterial activity; MATRIX-METALLOPROTEINASE INHIBITORS; HYDROXAMIC ACIDS; PEPTIDE DEFORMYLASE; ESTERS;

D O I：

10.1016/j.ejmech.2008.05.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel actinonin derivatives containing a benzimidazole heterocycle linked as amide isostere have been designed and synthesized. The structures of all the synthesized compounds were confirmed by analytical and spectroscopic methods. All the compounds were evaluated in vitro against Staphylococcus aureus, Klebsiella pneumoniae, and Sarcina lutea. Among them, compound la with unsubstituted benzimidazole ring exhibited potent antibacterial activities. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：2202 / 2210

页数：9

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