Disruption of the gut-liver axis in the pathogenesis of acute-on-chronic liver failure

被引：31

作者：

Zhang, Tao ^{[1
,4
]}

Sun, Kewei ^{[1
]}

Wang, Ya ^{[1
]}

Huang, Lei ^{[2
]}

Lang, Ren ^{[3
]}

Jiang, Wei ^{[4
,5
]}

机构：

[1] Hu Nan Univ Chinese Med, Affiliated Hosp 1, Changsha, Hunan, Peoples R China

[2] 302 Hosp PLA, Treatment & Res Ctr Infect Dis, Beijing, Peoples R China

[3] Capital Med Univ, Dept Hepatobiliary Surg, Beijing Chaoyang Hosp, Beijing 10020, Peoples R China

[4] Med Univ South Carolina, Dept Microbiol & Immunologys, Div Infect Dis, Charleston, SC USA

[5] Med Univ South Carolina, Dept Med, Div Infect Dis, Charleston, SC USA

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2018年 / 30卷 / 02期

基金：

北京市自然科学基金;

关键词：

acute-on-chronic liver failure; the gut-liver axis; toll-like receptor; TOLL-LIKE RECEPTORS; BACTERIAL TRANSLOCATION; SYSTEMIC INFLAMMATION; INTESTINAL MICROBIOTA; IMMUNE FUNCTION; KUPFFER CELLS; HEPATITIS-B; INFECTION; CIRRHOSIS; MECHANISMS;

D O I：

10.1097/MEG.0000000000001026

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Acute-on-chronic liver failure (ACLF) is characterized by organ failure mediated by acute decompensation of cirrhosis. Recent studies have highlighted the importance of the gut-liver axis (GLS) and its association with ACLF pathogenesis. In this review, we discuss the mechanisms related to the alteration of the GLA and their involvement in ACLF pathogenesis and suggest some possible therapeutic options that could modulate the GLA dysfunction. This knowledge may provide information useful for the design of therapeutic strategies for gut dysbiosis and its complications in ACLF. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：130 / 135

页数：6

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