Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study

被引:82
作者
van Aken, J
van Dongen, H
le Cessie, S
Allaart, CF
Breedveld, FC
Huizinga, TWJ
机构
[1] Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Med Stat, NL-2300 RC Leiden, Netherlands
关键词
D O I
10.1136/ard.2005.038471
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The outcome of undifferentiated arthritis (UA) ranges from remission to rheumatoid arthritis (RA) fulfilling the American College of Rheumatology (ACR) classification criteria. Objectives: To report the outcome of UA after 1 year of follow up and compare the disease course of patients who presented with UA, but evolved into RA within 1 year (UA-RA group), with that of patients who presented with RA fulfilling the ACR criteria (RA-RA group). Methods: The diagnosis of 330 patients who presented with UA was recorded at 1 year. The UA-RA and RA-RA groups were then followed up for 3 more years. Outcome measurements were radiographic progression, disease activity, and functional capacity. Results: From 330 patients who were diagnosed UA, 91 had evolved into RA at 1 year; 62 patients had presented with RA. No significant differences were detected between the UA-RA and RA-RA groups in median Sharp/van der Heijde score at baseline, radiographic progression rates, disease activity, and functional capacity. However, significantly more disease modifying antirheumatic drugs were prescribed in the RA-RA group. Conclusion: The disease outcome of patients who present with UA that evolves into RA within 1 year is the same as that of patients who present with RA as measured by radiographic progression, disease activity, and functional capacity.
引用
收藏
页码:20 / 25
页数:6
相关论文
共 21 条
  • [1] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS
    ARNETT, FC
    EDWORTHY, SM
    BLOCH, DA
    MCSHANE, DJ
    FRIES, JF
    COOPER, NS
    HEALEY, LA
    KAPLAN, SR
    LIANG, MH
    LUTHRA, HS
    MEDSGER, TA
    MITCHELL, DM
    NEUSTADT, DH
    PINALS, RS
    SCHALLER, JG
    SHARP, JT
    WILDER, RL
    HUNDER, GG
    [J]. ARTHRITIS AND RHEUMATISM, 1988, 31 (03): : 315 - 324
  • [2] MEASUREMENT OF PATIENT OUTCOME IN ARTHRITIS
    FRIES, JF
    SPITZ, P
    KRAINES, RG
    HOLMAN, HR
    [J]. ARTHRITIS AND RHEUMATISM, 1980, 23 (02): : 137 - 145
  • [3] SULFASALAZINE IN EARLY RHEUMATOID-ARTHRITIS - A 48-WEEK DOUBLE-BLIND, PROSPECTIVE, PLACEBO-CONTROLLED STUDY
    HANNONEN, P
    MOTTONEN, T
    HAKOLA, M
    OKA, M
    [J]. ARTHRITIS AND RHEUMATISM, 1993, 36 (11): : 1501 - 1509
  • [4] Criteria for early rheumatoid arthritis - From Bayes' law revisited to new thoughts on pathogenesis
    Huizinga, TWJ
    Machold, KP
    Breedveld, FC
    Lipsky, PE
    Smolen, JS
    [J]. ARTHRITIS AND RHEUMATISM, 2002, 46 (05): : 1155 - 1159
  • [5] Hulsmans HMJ, 2000, ARTHRITIS RHEUM, V43, P1927, DOI 10.1002/1529-0131(200009)43:9<1927::AID-ANR3>3.0.CO
  • [6] 2-B
  • [7] LONG-TERM PROGNOSIS OF MONOARTHRITIS - A FOLLOW-UP-STUDY
    KAARELA, K
    TIITINEN, S
    LUUKKAINEN, R
    [J]. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1983, 12 (04) : 374 - 376
  • [8] Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: Comparison of two cohorts who received different treatment strategies
    Lard, LR
    Visser, H
    Speyer, I
    vander Horst-Bruinsma, IE
    Zwinderman, AH
    Breedveld, FC
    Hazes, JMW
    [J]. AMERICAN JOURNAL OF MEDICINE, 2001, 111 (06) : 446 - 451
  • [9] Machold KP, 2002, J RHEUMATOL, V29, P2278
  • [10] Anti-CCP Antibody Detection Facilitates Early Diagnosis and Prognosis of Rheumatoid Arthritis
    Pruijn, Ger J. M.
    Vossenaar, Erik R.
    Drijfhout, Jan W.
    van Venrooiji, Walther J.
    Zendman, Albert J. W.
    [J]. CURRENT RHEUMATOLOGY REVIEWS, 2005, 1 (01) : 1 - 7