Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

被引：147

作者：

Brouwer, Matthijs C. ^{[1
]}

de Gans, Jan ^{[1
]}

Heckenberg, Sebastiaan G. B. ^{[1
]}

Zwinderman, Aeilko H. ^{[2
]}

van der Poll, Tom ^{[3
]}

van de Beek, Diederik ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, CINIMA, Dept Neurol, NL-1100 DD Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, CINIMA, Dept Clin Epidemiol Biostat & Bioinformat, NL-1100 DD Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, CINIMA, Ctr Expt & Mol Med, NL-1100 DD Amsterdam, Netherlands

来源：

LANCET INFECTIOUS DISEASES | 2009年 / 9卷 / 01期

关键词：

MANNOSE-BINDING LECTIN; TOLL-LIKE RECEPTOR-4; FC-GAMMA-RECEPTOR; STREPTOCOCCUS-PNEUMONIAE INFECTION; 4G/5G PROMOTER POLYMORPHISM; RECURRENT BACTERIAL-INFECTIONS; COMPLEMENT C7 DEFICIENCY; COMPONENT C6 DEFICIENCY; GENOME-WIDE ASSOCIATION; SEPTIC SHOCK;

D O I：

10.1016/S1473-3099(08)70261-5

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Streptococcus pneumoniae and Neisseria meningitidis can cause sepsis and meningitis. Several risk factors for pneumococcal and meningococcal disease have been identified, but the cause of basic differences in susceptibility between individuals and populations is unknown. Single-nucleotide polymorphisms are thought to explain interindividual differences in susceptibility. New technologies provide the opportunity to study the genetic basis of susceptibility to these diseases. In recent years, several studies have been published on these polymorphisms in pneumococcal and meningococcal. disease, many with apparently conflicting results. Herein we provide a systematic overview of all polymorphisms studied for a relation with susceptibility to pneumococcal and meningococcal disease. We also propose an initiative to pool genetic data on pneumococcal and meningococcal meningitis in one biobank.

引用

页码：31 / 44

页数：14

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