IL-2 Family of Cytokines in T Regulatory Cell Development and Homeostasis

被引:81
作者
Malek, Thomas R. [1 ,2 ]
Yu, Aixin [1 ]
Zhu, Linjian [1 ]
Matsutani, Takaji [1 ]
Adeegbe, Dennis [1 ]
Bayer, Allison L. [1 ,2 ]
机构
[1] Univ Miami, Dept Microbiol & Immunol, Miami, FL 33152 USA
[2] Univ Miami, Diabet Res Inst, Miller Sch Med, Miami, FL 33101 USA
关键词
IL-2R; IL-7R; Foxp3; thymic development; survival;
D O I
10.1007/s10875-008-9235-y
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Introduction Interleukin 2 (IL-2) induces an essential signal for T regulatory (Treg) cells. Without a functional IL-2R, only immature CD4(+) Foxp3(low) CD25(neg) T cells develop, and these cells fail to suppress autoreactive T cells in the periphery. Discussion IL-2 functions during Treg cell development by upregulating Foxp3 and CD25 and by increasing the number of thymic Treg cells. Upon exiting the thymus during neonatal life, IL-2 is responsible for rapid amplification of the number of Treg cells in peripheral lymph nodes to insure suppression of autoreactive T cells that escape negative selection, thereby maintaining tolerance. The homeostasis of Treg cells in mature immunocompetent mice also depends on IL-2. However, there is an alternative mechanism for Treg cells homeostasis that may represent a minor IL-2-independent pathway or the consequence of weak and very transient IL-2R signaling. Conclusion Thus, IL-2 provides importance signals for Treg cell development and for their homeostasis in peripheral immune tissues.
引用
收藏
页码:635 / 639
页数:5
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