One-dimensional diffusion of proteins along DNA - Its biological and chemical significance revealed by single-molecule measurements

被引：140

作者：

Shimamoto, N ^{[1
]}

机构：

[1] Natl Inst Genet, Struct Biol Ctr, Mishima, Shizuoka 4118540, Japan

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1999年 / 274卷 / 22期

关键词：

D O I：

10.1074/jbc.274.22.15293

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence for sliding of proteins along DNA has been provided by many kinetic studies, but single-molecule-based measurements have uncovered distinct problems, the solutions of which may lead us to an understanding of new mechanisms for gene regulation. Furthermore, they reveal a deep problem lying between chemistry and physics regarding the seemingly simple binding between DNA and protein. Single-molecule dynamics provides a tool to solve this problem without prejudgments or unsound assumptions.

引用

页码：15293 / 15296

页数：4

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