Effect of Atorvastatin (80 mg/day) versus Pravastatin (40 mg/day) on arterial remodeling at coronary branch points (from the REVERSAL study)

被引：16

作者：

Nicholls, SJ ^{[1
]}

Tuzcu, EM ^{[1
]}

Schoenhagen, P ^{[1
]}

Sipahi, I ^{[1
]}

Crowe, T ^{[1
]}

Kapadia, S ^{[1
]}

Nissen, SE ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 96卷 / 12期

关键词：

D O I：

10.1016/j.amjcard.2005.07.085

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of moderate and intensive lipid lowering on plaque progression and arterial remodeling at coronary branch points was investigated. Intensive (+ 1 +/- 19.6%), but not moderate (+ 4.1 +/- 15.1%), lipid lowering prevented an increase in plaque area at the branch points. The 2 strategies were associated with increased areas of the lumen (+7.6% to 9.4%) and external elastic membrane (+9.6% to 10.8%). In contrast, there was no significant change in plaque, lumen, and/or external elastic membrane areas at the nonbranch point site. These results suggest that intensive lipid lowering can have a dramatic effect on atheroma-prone regions and that remodeling in response to changes in plaque is a heterogenous process. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：1636 / 1639

页数：4

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