Donor ethnicity influences outcomes following deceased-donor kidney transplantation in black recipients

被引：22

作者：

Locke, Jayme E. ^{[1
]}

Warren, Daniel S. ^{[1
]}

Dominici, Francesca ^{[3
]}

Cameron, Andrew M. ^{[1
]}

Leffell, M. Sue ^{[2
]}

McRann, Deborah A. ^{[1
]}

Melancon, J. Keith ^{[1
]}

Segev, Dorry L. ^{[1
]}

Simpkins, Christopher E. ^{[1
]}

Singer, Andrew L. ^{[1
]}

Zachary, Andrea A. ^{[2
]}

Montgomery, Robert A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Surg, Div Transplantat, Johns Hopkins Med Inst,Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 10期

关键词：

D O I：

10.1681/ASN.2008010078

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Although the majority of deceased-donor kidneys are donated after brain death, increased recovery of kidneys donated after cardiac death could reduce the organ shortage and is now a national priority. Racial disparities in donations after brain death have been well described for renal transplantation, but it is unknown whether similar disparities occur in donations after cardiac death. In this study, outcomes of adult deceased-donor renal transplant recipients included in the United Network for Organ Sharing database (11993 through 2006) were analyzed. Among black recipients of kidneys obtained after cardiac death, those who received kidneys from black donors had better long-term graft and patient survival than those who received kidneys from white donors. In addition, compared with standard-criteria kidneys from white donors after brain death, kidneys from black donors after cardiac death conferred a 70% reduction in the risk for graft loss (adjusted hazard ratio 0.30; 95% confidence interval 0.14 to 0.65; P = 0.002) and a 59% reduction in risk for death (adjusted hazard ratio 0.41; 95% confidence interval 0.2 to 0.87; P = 0.02) among black recipients. These findings suggest that kidneys obtained from black donors after cardiac death may afford the best long-term survival for black recipients.

引用

页码：2011 / 2019

页数：9

共 37 条

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