Angiogenesis and inflammation face off

被引：133

作者：

Imhof, BA ^{[1
]}

Aurrand-Lions, M ^{[1
]}

机构：

[1] Ctr Med Univ Geneva, Dept Pathol & Immunol, Geneva, Switzerland

来源：

NATURE MEDICINE | 2006年 / 12卷 / 02期

关键词：

D O I：

10.1038/nm0206-171

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial cells respond to alarm signals of the body by angiogenesis or inflammation. The balance between these two responses is now pinned to two regulators of angiogenesis. Angiopoietin-1 dampens the inflammatory response, and angiopoietin-2 boosts it (pages 235–239).

引用

页码：171 / 172

页数：3

共 8 条

[1] Isolation of Angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [J].

Davis, S ;

Aldrich, TH ;

Jones, PF ;

Acheson, A ;

Compton, DL ;

Jain, V ;

Ryan, TE ;

Bruno, J ;

Radziejewski, C ;

Maisonpierre, PC ;

Yancopoulos, GD .

CELL, 1996, 87 (07) :1161-1169

[2] Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation [J].

Fiedler, U ;

Reiss, Y ;

Scharpfenecker, M ;

Grunow, V ;

Koidl, S ;

Thurston, G ;

Gale, NW ;

Witzenrath, M ;

Rosseau, S ;

Suttorp, N ;

Sobke, A ;

Herrmann, M ;

Preissner, KT ;

Vajkoczy, P ;

Augustin, HG .

NATURE MEDICINE, 2006, 12 (02) :235-239

[3] Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1 [J].

Gale, NW ;

Thurston, G ;

Hackett, SF ;

Renard, R ;

Wang, Q ;

McClain, J ;

Martin, C ;

Witte, C ;

Witte, MH ;

Jackson, D ;

Suri, C ;

Campochiaro, PA ;

Wiegand, SJ ;

Yancopoulos, GD .

DEVELOPMENTAL CELL, 2002, 3 (03) :411-423

[4] The antiinflammatory endothelial tyrosine kinase tie2 interacts with a novel nuclear factor-κB inhibitor ABIN-2 [J].

Hughes, DP ;

Marron, MB ;

Brindle, NPJ .

CIRCULATION RESEARCH, 2003, 92 (06) :630-636

[5]

JONES SE, 1967, INT J NONLIN MECH, V2, P257

[6] Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis [J].

Maisonpierre, PC ;

Suri, C ;

Jones, PF ;

Bartunkova, S ;

Wiegand, S ;

Radziejewski, C ;

Compton, D ;

McClain, J ;

Aldrich, TH ;

Papadopoulos, N ;

Daly, TJ ;

Davis, S ;

Sato, TN ;

Yancopoulos, GD .

SCIENCE, 1997, 277 (5322) :55-60

[7] TRAFFIC SIGNALS FOR LYMPHOCYTE RECIRCULATION AND LEUKOCYTE EMIGRATION - THE MULTISTEP PARADIGM [J].

SPRINGER, TA .

CELL, 1994, 76 (02) :301-314

[8] Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1 [J].

Thurston, G ;

Suri, C ;

Smith, K ;

McClain, J ;

Sato, TN ;

Yancopoulos, GD ;

McDonald, DM .

SCIENCE, 1999, 286 (5449) :2511-2514

← 1 →