The aging paradox: free radical theory of aging

被引：235

作者：

Ashok, BT ^{[1
]}

Ali, R ^{[1
]}

机构：

[1] Aligarh Muslim Univ, JN Med Coll, Dept Biochem, Aligarh 202002, Uttar Pradesh, India

来源：

EXPERIMENTAL GERONTOLOGY | 1999年 / 34卷 / 03期

关键词：

aging; autoantibodies; DNA damage; free radicals; reactive oxygen species;

D O I：

10.1016/S0531-5565(99)00005-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

There are more than 300 theories to explain the aging phenomenon. Many of them originate from the study of changes that accumulate with time. Among all the theories, the free radical theory of aging, postulated first by Harman, is the most popular and widely tested, and is based on the chemical nature and ubiquitous presence of free radicals. This review aims to recapitulate various studies on the role of free radicals in DNA damage-both nuclear as well as mitochondrial-the oxidative stress they impose on cells, the role of antioxidants, the presence of autoantibodies, and their overall impact on the aging process. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：293 / 303

页数：11

共 75 条

[1] Detection of oxidative DNA damage by a monoclonal antibody: role of lysyl residues in antigen binding
Ahmad, J
Ashok, BT
Ali, R
[J]. IMMUNOLOGY LETTERS, 1998, 62 (02) : 87 - 92
[2] MUTAGENESIS AND CARCINOGENESIS - ENDOGENOUS AND EXOGENOUS FACTORS
AMES, BN
[J]. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1989, 14 : 66 - 77
[3] ARTUR Y, 1992, FREE RADICALS AGING, P359
[4] Ashok BT, 1997, BIOCHEM MOL BIOL INT, V43, P1219
[5] Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe
Ashok, BT
Ali, R
[J]. MECHANISMS OF AGEING AND DEVELOPMENT, 1998, 103 (01) : 69 - 80
[6] Ashok BT, 1998, INT J CANCER, V78, P404, DOI 10.1002/(SICI)1097-0215(19981109)78:4<404::AID-IJC2>3.0.CO
[7] 2-Y
[8] ASHOK BT, 1999, IN PRESS AUTOIMMUNIT
[9] CHROMIUM-INDUCED EXCRETION OF URINARY LIPID METABOLITES, DNA-DAMAGE, NITRIC-OXIDE PRODUCTION, AND GENERATION OF REACTIVE OXYGEN SPECIES IN SPRAGUE-DAWLEY RATS
BAGCHI, D
HASSOUN, EA
BAGCHI, M
STOHS, SJ
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1995, 110 (02): : 177 - 187
[10] CEREBRAL ENZYME ANTIOXIDANT SYSTEM - INFLUENCE OF AGING AND PHOSPHATIDYLCHOLINE
BENZI, G
PASTORIS, O
MARZATICO, F
VILLA, RF
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (03) : 373 - 380

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