No mercy for messages that mess with the ribosome

被引：13

作者：

Clement, SL ^{[1
]}

Lykke-Andersen, J ^{[1
]}

机构：

[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2006年 / 13卷 / 04期

关键词：

D O I：

10.1038/nsmb0406-299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent study describes a novel mRNA-surveillance pathway called 'no- go decay' that triggers the endonucleolytic cleavage of yeast mRNAs with translation-elongation stalls. This adds to the repertoire of mRNA-decay processes in which abnormal translation may activate mRNA degradation through proteins recruited to the ribosomal A site.

引用

页码：299 / 301

页数：4

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