Prolactin and thyroid hormone levels are associated with suicide attempts in psychiatric patients

被引：95

作者：

Pompili, Maurizio ^{[1
,2
]}

Gibiino, Sara ^{[3
]}

Innamorati, Marco ^{[1
]}

Serafini, Gianluca ^{[1
]}

Del Casale, Antonio ^{[1
]}

De Risio, Luisa ^{[1
]}

Palermo, Mario ^{[1
]}

Montebovi, Franco ^{[1
]}

Campi, Sandra ^{[1
]}

De Luca, Vincenzo ^{[4
]}

Sher, Leo ^{[5
,6
]}

Tatarelli, Roberto ^{[1
]}

Biondi, Massimo ^{[8
]}

Duval, Fabrice ^{[7
]}

Serretti, Alessandro ^{[3
]}

Girardi, Paolo ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Suicide Prevent Ctr, St Andrea Hosp, I-00189 Rome, Italy

[2] Harvard Univ, Sch Med, McLean Hosp, Boston, MA USA

[3] Univ Bologna, Inst Psychiat, Bologna, Italy

[4] Univ Toronto, Dept Psychiat, CAMH, Toronto, ON, Canada

[5] Mt Sinai Sch Med, New York, NY USA

[6] James J Peters Vet Adm Med Ctr, New York, NY USA

[7] Ctr Hosp, Rouffach, France

[8] Univ Roma La Sapienza, Dept Psychiat & Psychol Med, I-00189 Rome, Italy

来源：

PSYCHIATRY RESEARCH | 2012年 / 200卷 / 2-3期

关键词：

Attempted suicide; Biological predictors; Mood disorder; Thyroid hormones; Depression; MAJOR DEPRESSIVE EPISODE; TOWER-OF-BABEL; REVISED NOMENCLATURE; BEHAVIOR; DISORDERS; METABOLITES; TESTS; MINI; AXIS; TRH;

D O I：

10.1016/j.psychres.2012.05.010

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The aim of this study is to evaluate biological factors associated with recent suicidal attempts in a naturalistic sample. A total of 439 patients suffering from major depression disorder (MDD), bipolar disorder (BD) and psychotic disorders (schizophrenia, schizoaffective disorder and psychosis not otherwise specified), who were consecutively assessed in the Emergency Department of an Italian Hospital (January 2008-December 2009), were included. In the whole sample, suicide attempters and non-attempters differed with regard to free triiodothyronine (FT3) and prolactin values only. A univariate general linear model indicated significant effects of sex (F-1;379=9.29; P=0.002), suicidal status (F-1;379=4.49; P=0.04) and the interaction between sex and suicidal status (F-1;379=5.17; P=0.02) on prolactin levels. A multinomial logistic regression model indicated that suicidal attempters were 2.27 times (odds ratio (OR)=0.44; 95% confidence interval (95%CI): 0.23/0.82; P=0.01) less likely to have higher FT3 values than non-attempters; while prolactin values failed to reach statistical significance (OR=0.99; 95%CI: 0.98/1.00; P=0.051). Both prolactin and thyroid hormones may be involved in a complex compensatory mechanism to correct reduced central serotonin activity. Further studies may help in understanding how these findings can be used by clinicians in assessing suicide risk. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：389 / 394

页数：6

共 30 条

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