Dietary vitamin C, beta-carotene and 30-year risk of stroke: Results from the Western Electric Study

被引:53
作者
Daviglus, ML
Orencia, AJ
Dyer, AR
Liu, K
Morris, DK
Persky, V
Chavez, N
Goldberg, J
Drum, M
Shekelle, RB
Stamler, J
机构
[1] INDIANA UNIV, SCH MED, DEPT NEUROL, INDIANAPOLIS, IN 46202 USA
[2] UNIV ILLINOIS, SCH PUBL HLTH, DIV EPIDEMIOL & BIOSTAT, CHICAGO, IL USA
[3] UNIV ILLINOIS, SCH PUBL HLTH, DIV COMMUNITY HLTH SERV, CHICAGO, IL USA
[4] UNIV TEXAS, HLTH SCI CTR, SCH PUBL HLTH, DEPT EPIDEMIOL, HOUSTON, TX USA
关键词
stroke; antioxidants; diet; health care financing; administration; population study;
D O I
10.1159/000109673
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The relations of dietary antioxidants vitamin C and beta-carotene to 30-year risk of stroke incidence and mortality were investigated prospectively in the Chicago Western Electric Study among 1,843 middle-aged men who remained free of cardiovascular disease through their second examination. Stroke mortality was ascertained from death certificates, and nonfatal stroke from records of the Health Care Financing Administration. During 46,102 person-years of follow-up, 222 strokes occurred; 76 of them were fatal. After adjustment for age, systolic blood pressure, cigarette smoking, body mass index, serum cholesterol, total energy intake, alcohol consumption, and diabetes, relative risks (and 95% confidence intervals) for nonfatal and fatal strokes (n = 222) in highest versus lowest quartiles of dietary beta-carotene and vitamin C intake were 0.84 (0.57-1.24) and 0.71 (0.47-1.05), respectively. Generally similar results were observed for fatal strokes (n = 76), Although there was a modest decrease in risk of stroke with higher intake of beta-carotene and vitamin-C intake, these data do not provide definitive evidence that high intake of antioxidant vitamins decreases risk of stroke.
引用
收藏
页码:69 / 77
页数:9
相关论文
共 45 条
  • [1] ACHESON RM, 1983, LANCET, V1, P1191
  • [2] Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group, 1994, N Engl J Med, V330, P1029, DOI 10.1056/NEJM199404143301501
  • [3] [Anonymous], FREE RADICALS AGING
  • [4] VITAMIN-C STATUS AND OTHER NUTRITIONAL INDEXES IN PATIENTS WITH STROKE AND OTHER ACUTE ILLNESSES - A CASE CONTROL STUDY
    BARER, D
    LEIBOWITZ, R
    EBRAHIM, S
    PENGALLY, D
    NEALE, R
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1989, 42 (07) : 625 - 631
  • [5] BOWES AP, 1956, FOOD VALUES PORTIONS
  • [6] RELATIONSHIP OF CARDIAC DISEASE TO STROKE OCCURRENCE, RECURRENCE, AND MORTALITY
    BRODERICK, JP
    PHILLIPS, SJ
    OFALLON, WM
    FRYE, RL
    WHISNANT, JP
    [J]. STROKE, 1992, 23 (09) : 1250 - 1256
  • [7] Burke Bertha S., 1947, JOUR AMER DIETETIC ASSOC, V23, P1041
  • [8] ACCURACY OF DEATH CERTIFICATION OF STROKE - THE FRAMINGHAM-STUDY
    CORWIN, LI
    WOLF, PA
    KANNEL, WB
    MCNAMARA, PM
    [J]. STROKE, 1982, 13 (06) : 818 - 821
  • [9] COX DR, 1972, J R STAT SOC B, V34, P187
  • [10] *DEP NUTR, 1957, FOOD COMP TABL